Hypoestrogenism

Hypoestrogenism
Other namesEstrogen deficiency
SpecialtyGynecology

Hypoestrogenism, or estrogen deficiency, refers to a lower than normal level of estrogen. It is an umbrella term used to describe estrogen deficiency in various conditions. Estrogen deficiency is also associated with an increased risk of cardiovascular disease,[1] and has been linked to diseases like urinary tract infections[2] and osteoporosis.

In women, low levels of estrogen may cause symptoms such as hot flashes, sleeping disturbances, decreased bone health,[3] and changes in the genitourinary system. Hypoestrogenism is most commonly found in women who are postmenopausal, have primary ovarian insufficiency (POI), or are presenting with amenorrhea (absence of menstrual periods). Hypoestrogenism includes primarily genitourinary effects, including thinning of the vaginal tissue layers and an increase in vaginal pH. With normal levels of estrogen, the environment of the vagina is protected against inflammation, infections, and sexually transmitted infections.[4] Hypoestrogenism can also occur in men, for instance due to hypogonadism.

There are both hormonal and non-hormonal treatments to prevent the negative effects of low estrogen levels and improve quality of life.

  1. ^ Cite error: The named reference Atsma2006 was invoked but never defined (see the help page).
  2. ^ Perrotta C, Aznar M, Mejia R, Albert X, Ng CW (April 2008). "Oestrogens for preventing recurrent urinary tract infection in postmenopausal women". Cochrane Database Syst Rev (2): CD005131. doi:10.1002/14651858.CD005131.pub2. PMID 18425910.
  3. ^ Prior JC (August 2018). "Progesterone for the prevention and treatment of osteoporosis in women". Climacteric. 21 (4): 366–374. doi:10.1080/13697137.2018.1467400. PMID 29962257. S2CID 49649035.
  4. ^ Cite error: The named reference Naumova2018 was invoked but never defined (see the help page).