IBA Lifesciences

IBA Lifesciences
IndustryBiotechnology
Founded1996
FounderDr. Herbert Stadler
Headquarters
Göttingen
,
Germany
Key people
Dr. Herbert Stadler (Founder & President)

Dr. Mike Rothe (CEO)

Dr. Joachim Bertram (CSO)
Number of employees
~50
Websitewww.iba-lifesciences.com

IBA Lifesciences is a biotechnology company providing products and custom specific services for life science applications in academia and industry worldwide.[1] IBA focusses on two business segments: cell selection and protein purification.[2]

The company is the original manufacturer and supplier of the Strep-tag/Strep-Tactin technology, an affinity chromatography system developed for protein purification.[3] The method is based on one of the strongest non-covalent interactions in nature, which is the interaction of biotin to streptavidin. An intrinsic binding affinity of the Strep-tag towards Strep-Tactin results in a highly specific interaction, which enables the isolation and purification of sensitive proteins in a native state as wells as intact protein complexes, respectively.[4][5] The technology was patented by the Max Planck Society (former “Garching Innovations”) and later assigned to IBA.[6][7] Recently, the method was further developed to be used for cell selection from whole blood or other single cell suspensions.[8]

  1. ^ "Göttinger Tageblatt - Außenwirtschaftspreis".
  2. ^ "VBio - 10 Jahre IBA. Ein Kurzporträt".
  3. ^ Schmidt, T. G.; Skerra, A. (2007). "The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins". Nat Protoc. 2 (6): 1528–1535. doi:10.1038/nprot.2007.209. PMID 17571060.
  4. ^ Schmidt, T. G.; Skerra, A. (2007). "The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins". Nat Protoc. 2 (6): 1528–1535. doi:10.1038/nprot.2007.209. PMID 17571060.
  5. ^ Skerra, A.; Schmidt, T. G. (2000). "Use of the Strep- tag and streptavidin for detection and purification of recombinant proteins". Use of the strep-tag and streptavidin for detection and purification of recombinant proteins. Methods Enzymol. Vol. 326. pp. 271–304. doi:10.1016/S0076-6879(00)26060-6. ISBN 978-0-12-182227-9. PMID 11036648.
  6. ^ "United States Patent - Streptavidin-binding peptide and uses thereof".
  7. ^ "United States Patent - Peptides with sequentially arranged streptavidin binding modules".
  8. ^ Pelák, O.; Kužílková, D.; Thürner, D.; Kiene, M. L.; Stanar, K.; Stuchlý, J.; Vášková, M.; Starý, J.; Hrušák, O.; Stadler, H.; Kalina, T. (2016). "Lymphocyte enrichment using CD81-targeted immunoaffinity matrix". Cytometry A. 91A: 62–72.