ICAM-1

ICAM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesICAM1, BB2, CD54, P3.58, intercellular adhesion molecule 1
External IDsOMIM: 147840; MGI: 96392; HomoloGene: 168; GeneCards: ICAM1; OMA:ICAM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000201

NM_010493

RefSeq (protein)

NP_000192

NP_034623

Location (UCSC)Chr 19: 10.27 – 10.29 MbChr 9: 20.93 – 20.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene.[5][6] This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090339Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037405Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Carlson M, Nakamura Y, Payson R, O'Connell P, Leppert M, Lathrop GM, Lalouel JM, White R (May 1988). "Isolation and mapping of a polymorphic DNA sequence (pMCT108.2) on chromosome 18 [D18S24]". Nucleic Acids Research. 16 (9): 4188. doi:10.1093/nar/16.9.4188. PMC 336612. PMID 2453850.
  6. ^ Katz FE, Parkar M, Stanley K, Murray LJ, Clark EA, Greaves MF (Jan 1985). "Chromosome mapping of cell membrane antigens expressed on activated B cells". European Journal of Immunology. 15 (1): 103–06. doi:10.1002/eji.1830150121. PMID 3871395. S2CID 6571761.
  7. ^ "Entrez Gene: intercellular adhesion molecule 1".