Protein-coding gene in the species Homo sapiens
Protein-S -isoprenylcysteine O -methyltransferase is an enzyme that in humans is encoded by the ICMT gene .[ 5] [ 6] [ 7]
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane . This enzyme localizes to the endoplasmic reticulum . Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000116237 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039662 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR (Jul 1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum" . J Biol Chem . 273 (24): 15030–4. doi :10.1074/jbc.273.24.15030 PMID 9614111 . ^ Desrosiers RR, Nguyen QT, Beliveau R (Sep 1999). "The carboxyl methyltransferase modifying G proteins is a metalloenzyme". Biochem Biophys Res Commun . 261 (3): 790–7. doi :10.1006/bbrc.1999.0936 . PMID 10441503 . ^ a b "Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase" . 
