IDPN (chemical)

IDPN
Names
Preferred IUPAC name
3,3′-Azanediyldipropanenitrile
Other names
Bis(2-cyanoethyl)amine
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.003.566 Edit this at Wikidata
EC Number
  • 203-922-3
UNII
UN number 3334
  • InChI=1S/C6H9N3/c7-3-1-5-9-6-2-4-8/h9H,1-2,5-6H2
    Key: SBAJRGRUGUQKAF-UHFFFAOYSA-N
  • C(CNCCC#N)C#N
Properties
C6H9N3
Molar mass 123.159 g·mol−1
Density 1.02
Melting point −5.5 °C (22.1 °F; 267.6 K)
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

IDPN (3,3'-iminodipropanenitrile) is a neurotoxin with ototoxic and hepatotoxic effects. It causes irreversible movement disorder.[1][2][3]

  1. ^ Sedó-Cabezón, Lara; Jedynak, Paulina; Boadas-Vaello, Pere; Llorens, Jordi (1 October 2015). "Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats". Disease Models & Mechanisms. 8 (10): 1323–1337. doi:10.1242/dmm.021436. PMC 4610239. PMID 26398945.
  2. ^ Khan, HA; Ibrahim, KE (12 October 2015). "Pattern of neurobehavioral and organ-specific toxicities of β, β'-iminodipropionitrile in mice". Archives of Medical Science. 11 (5): 1137–44. doi:10.5114/aoms.2015.54871 (inactive 1 November 2024). PMC 4624758. PMID 26528360.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
  3. ^ Ogata, Keiko; Kushida, Masahiko; Miyata, Kaori; Sumida, Kayo; Takeda, Shuji; Izawa, Takeshi; Kuwamura, Mitsuru; Yamate, Jyoji (2016). "Alteration of microRNA expressions in the pons and medulla in rats after 3,3′-iminodipropionitrile administration". Journal of Toxicologic Pathology. 29 (4): 229–236. doi:10.1293/tox.2016-0019. PMC 5097965. PMID 27821907.