Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene.[5][6][7] It plays a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked.[8] This observation has been further advanced by a recent study from Paul Kellam's lab that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1.[9] The prevalence of this mutation is thought to be approximately 1/400 in European populations.[9][10]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142089 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025492 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lewin AR, Reid LE, McMahon M, Stark GR, Kerr IM (Aug 1991). "Molecular analysis of a human interferon-inducible gene family". Eur J Biochem. 199 (2): 417–423. doi:10.1111/j.1432-1033.1991.tb16139.x. PMID 1906403.
- ^ Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP (Dec 2005). "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion". Dev Cell. 9 (6): 745–756. doi:10.1016/j.devcel.2005.10.010. PMID 16326387.
- ^ "Entrez Gene: IFITM3 interferon induced transmembrane protein 3 (1-8U)".
- ^ "Natural swine flu defence found". Archived from the original on December 20, 2009.
- ^ a b Everitt A.R.; et al. (March 2012). "IFITM3 restricts the morbidity and mortality associated with influenza". Nature. 484 (7395): 519–23. Bibcode:2012Natur.484..519.. doi:10.1038/nature10921. PMC 3648786. PMID 22446628.
- ^ "Gene flaw linked to serious flu risk". BBC News. 25 March 2012.