IGF2BP1

IGF2BP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIGF2BP1, CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1
External IDsOMIM: 608288; MGI: 1890357; HomoloGene: 4772; GeneCards: IGF2BP1; OMA:IGF2BP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001160423
NM_006546

NM_009951

RefSeq (protein)

NP_001153895
NP_006537

NP_034081
NP_001388383
NP_001388384
NP_001388385
NP_001388386

Location (UCSC)Chr 17: 49 – 49.06 MbChr 11: 95.96 – 96.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.[5][6][7]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159217Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013415Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.
  6. ^ Yaniv K, Yisraeli JK (May 2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene. 287 (1–2): 49–54. doi:10.1016/S0378-1119(01)00866-6. PMID 11992722.
  7. ^ a b "Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1".