IGFBP1

IGFBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZT3, 1ZT5, 2DSQ
Identifiers
Aliases	IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1, insulin like growth factor binding protein 1
External IDs	OMIM: 146730; MGI: 96436; HomoloGene: 498; GeneCards: IGFBP1; OMA:IGFBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	45,893,660 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	7,152,546 bp
RNA expression pattern
	Top expressed in
	decidua; ; right lobe of liver; ; oocyte; ; secondary oocyte; ; gonad; ; stromal cell of endometrium; ; testicle; ; left ovary; ; right ovary; ; pericardium;
	Top expressed in
	left lobe of liver; ; right lobe of liver; ; human fetus; ; sexually immature organism; ; embryo; ; yolk sac; ; human kidney; ; right kidney; ; cumulus cell; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; insulin-like growth factor II binding; insulin-like growth factor binding; growth factor binding; insulin-like growth factor I binding; protein binding;
Cellular component	extracellular region; Golgi apparatus; extracellular space; endoplasmic reticulum lumen;
Biological process	PERK-mediated unfolded protein response; tissue regeneration; insulin receptor signaling pathway; regulation of cell growth; negative regulation of canonical Wnt signaling pathway; signal transduction; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of cell growth; human ageing; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	3484
	16006
	ENSG00000146678
	ENSMUSG00000020429
	P08833
	P47876
	NM_001013029; NM_000596
	NM_008341
	NP_000587
	NP_032367
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146678 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020429 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brinkman A, Groffen C, Kortleve DJ, Geurts van Kessel A, Drop SL (Jan 1989). "Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)". EMBO J. 7 (8): 2417–23. doi:10.1002/j.1460-2075.1988.tb03087.x. PMC 457109. PMID 2461294.
^ "Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146678 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020429 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2461294-5] Brinkman A, Groffen C, Kortleve DJ, Geurts van Kessel A, Drop SL (Jan 1989). "Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)". EMBO J. 7 (8): 2417–23. doi:10.1002/j.1460-2075.1988.tb03087.x. PMC 457109. PMID 2461294.

[entrez-6] "Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1".

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