IGFBP3

IGFBP3
Identifiers
Aliases	IGFBP3, BP-53, IBP3, insulin like growth factor binding protein 3
External IDs	OMIM: 146732; MGI: 96438; HomoloGene: 500; GeneCards: IGFBP3; OMA:IGFBP3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p12.3 Start 45,912,245 bp[1] End 45,921,874 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 4.75 cM Start 7,156,086 bp[2] End 7,163,923 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua palpebral conjunctiva cartilage tissue Descending thoracic aorta mucosa of urinary bladder vulva pericardium skin of thigh skin of hip right lobe of liver Top expressed in Gonadal ridge gastrula molar vestibular sensory epithelium skin of external ear external carotid artery efferent ductule right kidney lip human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibronectin binding insulin-like growth factor binding protein tyrosine phosphatase activator activity growth factor binding insulin-like growth factor I binding metal ion binding insulin-like growth factor II binding protein binding Cellular component insulin-like growth factor ternary complex extracellular region insulin-like growth factor binding protein complex nucleus extracellular space endoplasmic reticulum lumen Biological process negative regulation of protein phosphorylation negative regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell migration protein phosphorylation regulation of insulin-like growth factor receptor signaling pathway regulation of glucose metabolic process positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of myoblast differentiation regulation of cell growth osteoblast differentiation positive regulation of apoptotic process regulation of growth negative regulation of signal transduction type B pancreatic cell proliferation positive regulation of MAPK cascade negative regulation of cell population proliferation apoptotic process regulation of apoptotic process post-translational protein modification regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3486 16009 Ensembl ENSG00000146674 ENSMUSG00000020427 UniProt P17936 P47878 RefSeq (mRNA) NM_001013398 NM_000598 NM_008343 RefSeq (protein) NP_000589 NP_001013416 NP_032369 Location (UCSC) Chr 7: 45.91 – 45.92 Mb Chr 11: 7.16 – 7.16 Mb PubMed search [3] [4]
Wikidata
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Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity. IGFBP-7, sometimes included in this family, shares neither the conserved structural features nor the high IGF affinity. Instead, IGFBP-7 binds IGF1R, which blocks IGF-1 and IGF-2 binding, resulting in apoptosis.^[5]