IKZF4

IKZF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MA7
Identifiers
Aliases	IKZF4, EOS, ZNFN1A4, IKAROS family zinc finger 4
External IDs	OMIM: 606239; MGI: 1343139; HomoloGene: 69103; GeneCards: IKZF4; OMA:IKZF4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,038,435 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,505,227 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; left adrenal gland; ; adrenal cortex; ; left adrenal cortex; ; right adrenal gland; ; inferior ganglion of vagus nerve; ; muscle of thigh; ; right adrenal cortex; ; testicle; ; gastrocnemius muscle;
	Top expressed in
	Rostral migratory stream; ; secondary oocyte; ; zygote; ; primary oocyte; ; medulla of thymus; ; female urethra; ; trigeminal ganglion; ; suprachiasmatic nucleus; ; supraoptic nucleus; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; nucleic acid binding; sequence-specific DNA binding; DNA binding; bHLH transcription factor binding; protein homodimerization activity; metal ion binding; protein heterodimerization activity; zinc ion binding; protein domain specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; nuclear body; protein-containing complex;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; protein homooligomerization; protein heterooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	64375
	22781
	ENSG00000123411
	ENSMUSG00000002578
	Q9H2S9
	Q8C208
	NM_022465; NM_001351089; NM_001351090; NM_001351091; NM_001351092
	NM_011772; NM_001358536; NM_001358537
	NP_071910; NP_001338018; NP_001338019; NP_001338020; NP_001338021
	NP_035902; NP_001345465; NP_001345466
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.^[5]^[6]

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123411 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002578 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
^ ^a ^b "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123411 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002578 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10978333-5] Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.

[entrez-6] "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".

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