IL12A

IL12A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F45, 3HMX
Identifiers
Aliases	IL12A, CLMF, IL-12A, NFSK, NKSF1, P35, interleukin 12A
External IDs	OMIM: 161560; MGI: 96539; HomoloGene: 681; GeneCards: IL12A; OMA:IL12A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	159,996,019 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	68,605,880 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; right uterine tube; ; ventricular zone; ; olfactory zone of nasal mucosa; ; upper lobe of left lung; ; spleen; ; granulocyte; ; stromal cell of endometrium; ; amygdala;
	Top expressed in
	muscle of thigh; ; embryo; ; knee joint; ; triceps brachii muscle; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; granulocyte; ; tibiofemoral joint; ; gastrocnemius muscle; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; interleukin-27 binding; interleukin-12 beta subunit binding; protein binding; protein heterodimerization activity; growth factor activity; interleukin-12 receptor binding;
Cellular component	cytoplasm; interleukin-12 complex; extracellular region; extracellular space; endoplasmic reticulum lumen; late endosome lumen; cell surface;
Biological process	positive regulation of T cell differentiation; negative regulation of smooth muscle cell proliferation; extrinsic apoptotic signaling pathway; positive regulation of smooth muscle cell apoptotic process; response to virus; positive regulation of T cell mediated cytotoxicity; positive regulation of interferon-gamma production; positive regulation of natural killer cell activation; positive regulation of NK T cell activation; response to lipopolysaccharide; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; immune response; response to UV-B; cellular response to lipopolysaccharide; negative regulation of interleukin-17 production; cell migration; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of lymphocyte proliferation; positive regulation of dendritic cell chemotaxis; positive regulation of mononuclear cell proliferation; positive regulation of cell adhesion; defense response to protozoan; defense response to Gram-positive bacterium; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; interleukin-12-mediated signaling pathway; cell population proliferation; regulation of signaling receptor activity; T-helper 1 cell cytokine production; cytokine-mediated signaling pathway; interleukin-35-mediated signaling pathway; T-helper 1 cell activation;
	Sources:Amigo / QuickGO
Orthologs
	3592
	16159
	ENSG00000168811
	ENSMUSG00000027776
	P29459
	P43431
	NM_000882; NM_001354582; NM_001354583; NM_001397992
	NM_001159424; NM_008351
	NP_000873; NP_001341511; NP_001341512
	NP_001152896; NP_032377
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-12 subunit alpha (IL-12 p35) is a protein that in humans is encoded by the IL12A gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168811 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027776 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM (May 1991). "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells". J Immunol. 146 (9): 3074–81. doi:10.4049/jimmunol.146.9.3074. PMID 1673147. S2CID 23838991.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168811 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027776 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1673147-5] Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM (May 1991). "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells". J Immunol. 146 (9): 3074–81. doi:10.4049/jimmunol.146.9.3074. PMID 1673147. S2CID 23838991.

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