IL17RB

IL17RB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VBC
Identifiers
Aliases	IL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDs	OMIM: 605458; MGI: 1355292; HomoloGene: 10287; GeneCards: IL17RB; OMA:IL17RB - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	53,865,794 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	29,730,853 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; right lobe of liver; ; human kidney; ; mucosa of ileum; ; right hemisphere of cerebellum; ; glomerulus; ; amygdala; ; metanephric glomerulus; ; caudate nucleus; ; nucleus accumbens;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; thymus; ; zygote; ; right kidney; ; proximal tubule; ; pharynx; ; morula; ; vestibular membrane of cochlear duct; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; interleukin-17 receptor activity;
Cellular component	cytoplasm; integral component of membrane; extracellular region; cell surface; integral component of plasma membrane; membrane; plasma membrane;
Biological process	defense response; positive regulation of inflammatory response; regulation of cell growth; interleukin-17-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55540
	50905
	ENSG00000056736
	ENSMUSG00000015966
	Q9NRM6
	Q9JIP3
	NM_018725; NM_172234
	NM_019583
	NP_061195
	NP_062529
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.^[5]^[6]^[7]

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000056736 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015966 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity". J Biol Chem. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.
^ Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene. 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801. S2CID 27521628.
^ ^a ^b "Entrez Gene: IL17RB interleukin 17 receptor B".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000056736 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015966 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10749887-5] Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity". J Biol Chem. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.

[pmid10815801-6] Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene. 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801. S2CID 27521628.

[entrez-7] "Entrez Gene: IL17RB interleukin 17 receptor B".

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