IL31RA

IL31RA
Identifiers
Aliases	IL31RA, CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, interleukin 31 receptor A, zcytoR17
External IDs	OMIM: 609510; MGI: 2180511; HomoloGene: 51395; GeneCards: IL31RA; OMA:IL31RA - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	55,922,854 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	112,730,894 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; monocyte; ; thoracic aorta; ; ascending aorta; ; spinal ganglia; ; Descending thoracic aorta; ; granulocyte; ; trigeminal ganglion; ; tibia;
	Top expressed in
	lumbar spinal ganglion; ; zygote; ; secondary oocyte; ; primary oocyte; ; seminal vesicula; ; embryo; ; spermatid; ; morula; ; ventricular zone; ; Rostral migratory stream;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; cytokine receptor activity; protein kinase binding; cytokine binding;
Cellular component	membrane; external side of plasma membrane; plasma membrane; synapse; cell junction; integral component of membrane; axon; intracellular anatomical structure; presynaptic membrane; cell projection; receptor complex;
Biological process	defense response; receptor signaling pathway via JAK-STAT; transmembrane receptor protein tyrosine kinase signaling pathway; cytokine-mediated signaling pathway; immune system process; defense response to other organism; negative regulation of macrophage activation; negative regulation of apoptotic process; acute inflammatory response to antigenic stimulus; monocyte differentiation; macrophage differentiation; MAPK cascade; positive regulation of transcription, DNA-templated; glandular epithelial cell differentiation; positive regulation of cell population proliferation; T-helper 2 cell cytokine production; homeostatic process; positive regulation of tyrosine phosphorylation of STAT protein;
	Sources:Amigo / QuickGO
Orthologs
	133396
	218624
	ENSG00000164509
	ENSMUSG00000050377
	Q8NI17
	Q8K5B1
NM_001242636; NM_001242637; NM_001242638; NM_001242639; NM_001297570;
	NM_001297572; NM_139017
	NM_139299
NP_001229565; NP_001229566; NP_001229567; NP_001229568; NP_001284499;
	NP_001284501; NP_620586
	NP_647460
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.^[5]^[6]^[7]

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164509 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (Jun 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896. S2CID 12442845.
^ Ghilardi N, Li J, Hongo JA, Yi S, Gurney A, de Sauvage FJ (May 2002). "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5". J Biol Chem. 277 (19): 16831–6. doi:10.1074/jbc.M201140200. PMID 11877449.
^ ^a ^b "Entrez Gene: IL31RA interleukin 31 receptor A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164509 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050377 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15184896-5] Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (Jun 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896. S2CID 12442845.

[pmid11877449-6] Ghilardi N, Li J, Hongo JA, Yi S, Gurney A, de Sauvage FJ (May 2002). "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5". J Biol Chem. 277 (19): 16831–6. doi:10.1074/jbc.M201140200. PMID 11877449.

[entrez-7] "Entrez Gene: IL31RA interleukin 31 receptor A".

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