IRAK1

IRAK1
Identifiers
Aliases	IRAK1, IRAK, pelle, interleukin 1 receptor associated kinase 1
External IDs	OMIM: 300283; MGI: 107420; HomoloGene: 37496; GeneCards: IRAK1; OMA:IRAK1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,010,506 bp[1] End 154,019,902 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 37.61 cM Start 73,057,520 bp[2] End 73,067,524 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland pancreatic ductal cell endothelial cell gingival epithelium periodontal fiber duodenum epithelium of esophagus mucosa of ileum stromal cell of endometrium granulocyte Top expressed in lacrimal gland parotid gland submandibular gland lobe of prostate Paneth cell islet of Langerhans seminal vesicula tunica media of zone of aorta tunica adventitia of aorta body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding heat shock protein binding protein homodimerization activity kinase activity NF-kappaB-inducing kinase activity protein binding protein heterodimerization activity ATP binding protein serine/threonine kinase activity Cellular component membrane lipid droplet plasma membrane endosome membrane interleukin-1 receptor complex nucleus cytoplasm cytosol Biological process cellular response to heat response to interleukin-1 positive regulation of MAP kinase activity regulation of cytokine-mediated signaling pathway phosphorylation cytokine-mediated signaling pathway immune system process human ageing negative regulation of apoptotic process activation of NF-kappaB-inducing kinase activity MyD88-dependent toll-like receptor signaling pathway toll-like receptor signaling pathway positive regulation of transcription, DNA-templated protein phosphorylation JNK cascade response to lipopolysaccharide transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of NF-kappaB transcription factor activity protein complex oligomerization positive regulation of I-kappaB kinase/NF-kappaB signaling protein autophosphorylation toll-like receptor 9 signaling pathway cellular response to lipopolysaccharide negative regulation of NF-kappaB transcription factor activity nucleotide-binding oligomerization domain containing signaling pathway positive regulation of type I interferon production cellular response to hypoxia lipopolysaccharide-mediated signaling pathway signal transduction positive regulation of smooth muscle cell proliferation toll-like receptor 4 signaling pathway toll-like receptor 2 signaling pathway innate immune response type I interferon signaling pathway viral process interleukin-1-mediated signaling pathway intracellular signal transduction positive regulation of NIK/NF-kappaB signaling positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3654 16179 Ensembl ENSG00000184216 ENSMUSG00000031392 UniProt P51617 Q62406 RefSeq (mRNA) NM_001025242 NM_001025243 NM_001569 NM_001177973 NM_001177974 NM_001177975 NM_001177976 NM_008363 RefSeq (protein) NP_001020413 NP_001020414 NP_001560 NP_001171444 NP_001171445 NP_001171446 NP_001171447 NP_032389 Location (UCSC) Chr X: 154.01 – 154.02 Mb Chr X: 73.06 – 73.07 Mb PubMed search [3] [4]
Wikidata
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Interleukin-1 receptor-associated kinase 1 (IRAK-1) is an enzyme in humans encoded by the IRAK1 gene.^[5][6] IRAK-1 plays an important role in the regulation of the expression of inflammatory genes by immune cells, such as monocytes and macrophages, which in turn help the immune system in eliminating bacteria, viruses, and other pathogens. IRAK-1 is part of the IRAK family consisting of IRAK-1, IRAK-2, IRAK-3, and IRAK-4, and is activated by inflammatory molecules released by signaling pathways during pathogenic attack.^[7] IRAK-1 is classified as a kinase enzyme, which regulates pathways in both innate and adaptive immune systems.^[8]