IRF1

IRF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IF1
Identifiers
Aliases	IRF1, IRF-1, MAR, interferon regulatory factor 1
External IDs	OMIM: 147575; MGI: 96590; HomoloGene: 1658; GeneCards: IRF1; OMA:IRF1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,669,200 bp
RNA expression pattern
	n/a
	Top expressed in
	granulocyte; ; jejunum; ; mesenteric lymph nodes; ; duodenum; ; corneal stroma; ; large intestine; ; spleen; ; colon; ; ileum; ; primary oocyte;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; nucleoplasm; nucleus;
Biological process	apoptotic process; regulation of CD8-positive, alpha-beta T cell proliferation; CD8-positive, alpha-beta T cell differentiation; regulation of innate immune response; negative regulation of regulatory T cell differentiation; regulation of transcription, DNA-templated; cellular response to interferon-beta; interferon-gamma-mediated signaling pathway; immune system process; regulation of adaptive immune response; blood coagulation; regulation of MyD88-dependent toll-like receptor signaling pathway; transcription by RNA polymerase II; transcription, DNA-templated; regulation of cell cycle; positive regulation of transcription, DNA-templated; cellular response to mechanical stimulus; defense response to virus; type I interferon signaling pathway; regulation of immune response; regulation of gene expression; innate immune response; negative regulation of transcription, DNA-templated; positive regulation of type I interferon production; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; positive regulation of interferon-beta production;
	Sources:Amigo / QuickGO
Orthologs
	3659
	16362
	ENSG00000125347
	ENSMUSG00000018899
	P10914
	P15314
	NM_002198
	NM_001159393; NM_001159396; NM_008390
	NP_002189; NP_001341853; NP_001341854
	NP_001152865; NP_001152868; NP_032416
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.^[4]^[5]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018899 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maruyama M, Fujita T, Taniguchi T (Jun 1989). "Sequence of a cDNA coding for human IRF-1". Nucleic Acids Res. 17 (8): 3292. doi:10.1093/nar/17.8.3292. PMC 317732. PMID 2726461.
^ Itoh S, Harada H, Nakamura Y, White R, Taniguchi T (Nov 1991). "Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31". Genomics. 10 (4): 1097–9. doi:10.1016/0888-7543(91)90208-V. PMID 1680796.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000018899 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2726461-4] Maruyama M, Fujita T, Taniguchi T (Jun 1989). "Sequence of a cDNA coding for human IRF-1". Nucleic Acids Res. 17 (8): 3292. doi:10.1093/nar/17.8.3292. PMC 317732. PMID 2726461.

[pmid1680796-5] Itoh S, Harada H, Nakamura Y, White R, Taniguchi T (Nov 1991). "Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31". Genomics. 10 (4): 1097–9. doi:10.1016/0888-7543(91)90208-V. PMID 1680796.

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