IRS2

IRS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FQW, 3FQX
Identifiers
Aliases	IRS2, IRS-2, insulin receptor substrate 2
External IDs	OMIM: 600797; MGI: 109334; HomoloGene: 2778; GeneCards: IRS2; OMA:IRS2 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	109,786,583 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	11,058,458 bp
RNA expression pattern
	Top expressed in
	decidua; ; Region I of hippocampus proper; ; postcentral gyrus; ; dorsal motor nucleus of vagus nerve; ; mucosa of paranasal sinus; ; orbitofrontal cortex; ; Brodmann area 46; ; lateral nuclear group of thalamus; ; entorhinal cortex; ; middle temporal gyrus;
	Top expressed in
	skin of toe; ; tail of embryo; ; Rostral migratory stream; ; molar; ; muscle of thigh; ; genital tubercle; ; primary visual cortex; ; superior frontal gyrus; ; entorhinal cortex; ; cerebellar cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	insulin receptor binding; 14-3-3 protein binding; phosphatidylinositol 3-kinase binding; protein binding; protein kinase binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; signal transducer activity; protein phosphatase binding; protein domain specific binding;
Cellular component	cytoplasm; cytosol; plasma membrane; protein-containing complex;
Biological process	positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; cellular response to peptide; positive regulation of cell migration; positive regulation of glucose metabolic process; response to glucose; MAPK cascade; mammary gland development; regulation of lipid metabolic process; negative regulation of long-chain fatty acid import across plasma membrane; brain development; positive regulation of mesenchymal cell proliferation; positive regulation of B cell proliferation; positive regulation of cell population proliferation; lipid homeostasis; glucose metabolic process; cellular response to insulin stimulus; negative regulation of B cell apoptotic process; cell population proliferation; phosphatidylinositol-mediated signaling; cellular response to glucose stimulus; signal transduction; positive regulation of insulin secretion; negative regulation of kinase activity; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol phosphate biosynthetic process; insulin receptor signaling pathway; axon guidance; interleukin-7-mediated signaling pathway; positive regulation of protein kinase B signaling; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	8660
	384783
	ENSG00000185950
	ENSMUSG00000038894
	Q9Y4H2
	P81122
	NM_003749
	NM_001081212
	NP_003740
	NP_001074681
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185950 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038894 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T (Oct 1997). "14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain". J Biol Chem. 272 (40): 25267–74. doi:10.1074/jbc.272.40.25267. PMID 9312143.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185950 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038894 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9312143-5] Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T (Oct 1997). "14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain". J Biol Chem. 272 (40): 25267–74. doi:10.1074/jbc.272.40.25267. PMID 9312143.

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