IZUMO1

IZUMO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5JKD, 5F4T, 5JKC, 5JK9, 5JKE, 5F4V, 5F4E
Identifiers
Aliases	IZUMO1, IZUMO, OBF, izumo sperm-egg fusion 1
External IDs	OMIM: 609278; MGI: 1920706; HomoloGene: 77701; GeneCards: IZUMO1; OMA:IZUMO1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,746,909 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,628,823 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; sperm; ; body of pancreas; ; upper lobe of left lung; ; right hemisphere of cerebellum; ; body of stomach; ; right adrenal cortex; ; right lung; ; apex of heart;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; embryo; ; blastocyst; ; embryo; ; yolk sac; ; epiblast; ; lip; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding; protein homodimerization activity; protein binding; identical protein binding; protein binding involved in heterotypic cell-cell adhesion;
Cellular component	membrane; integral component of membrane; plasma membrane; acrosomal membrane; cytoplasmic vesicle;
Biological process	cell adhesion; sperm-egg recognition; single fertilization; fusion of sperm to egg plasma membrane involved in single fertilization; heterotypic cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	284359
	73456
	ENSG00000182264
	ENSMUSG00000064158
	Q8IYV9
	Q9D9J7
	NM_182575; NM_001321864; NM_001321865
	NM_001018013
	NP_001308793; NP_001308794; NP_872381
	NP_001018013
	Wikidata
View/Edit Human	View/Edit Mouse

Izumo sperm-egg fusion protein 1 (Sperm-specific protein izumo) is encoded in humans by the IZUMO1 gene.^[5] In mammalian fertilisation, IZUMO1 binds to its egg receptor counterpart, Juno, to facilitate recognition and fusion of the gametes. ^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182264 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000064158 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Izumo sperm-egg fusion 1".
^ Bianchi, Enrica, et al. "Juno is the egg Izumo receptor and is essential for mammalian fertilization." Nature 508.7497 (2014): 483.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182264 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000064158 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Izumo sperm-egg fusion 1".

[6] Bianchi, Enrica, et al. "Juno is the egg Izumo receptor and is essential for mammalian fertilization." Nature 508.7497 (2014): 483.

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