 | |
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Mouse |
| Target | CD20 |
| Clinical data | |
| Trade names | Zevalin |
| AHFS/Drugs.com | Monograph |
| License data | |
| Routes of administration | Intravenous |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| DrugBank | |
| ChemSpider |
|
| UNII | |
| KEGG | |
| ChEMBL | |
  (what is this?) (verify) | |
Ibritumomab tiuxetan (pronounced /ɪbrɪˈtuːmoʊmæb taɪˈʌksɛtæn/[2]), sold under the trade name Zevalin, is a monoclonal antibody radioimmunotherapy treatment for non-Hodgkin's lymphoma. The drug uses the monoclonal mouse IgG1 antibody ibritumomab in conjunction with the chelator tiuxetan, to which a radioactive isotope (either yttrium-90 or indium-111) is added. Tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group.[3][4]
- ^ "Zevalin EPAR". European Medicines Agency. 2 March 2009. Retrieved 11 July 2024.
- ^ "Ibritumomab Tiuxetan". National Cancer Institute. 26 February 2008. Retrieved 25 July 2020.
- ^ Milenic DE, Brady ED, Brechbiel MW (June 2004). "Antibody-targeted radiation cancer therapy". Nature Reviews. Drug Discovery. 3 (6): 488–99. doi:10.1038/nrd1413. PMID 15173838. S2CID 22166498.
- ^ WHO Drug Information