Ibudilast

Ibudilast
Clinical data
Trade names	Ketas, Pinatos, Eyevinal
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth (capsules),; topical (ophthalmic solution)
ATC code	R03DC04 (WHO) ;
Legal status
Legal status	Rx-only (JP KR);
Identifiers
	IUPAC name 2-Methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one;
CAS Number	50847-11-5 ;
PubChem CID	3671;
IUPHAR/BPS	7399;
DrugBank	DB05266 ;
ChemSpider	3543 ;
UNII	M0TTH61XC5;
KEGG	D01385 ;
ChEMBL	ChEMBL19449 ;
CompTox Dashboard (EPA)	DTXSID7049007 ;
ECHA InfoCard	100.164.881
Chemical and physical data
Formula	C14H18N2O
Molar mass	230.311 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C(=O)c1c(nn2ccccc12)C(C)C;
	InChI InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3 ; Key:ZJVFLBOZORBYFE-UHFFFAOYSA-N ;
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Ibudilast (development codes: AV-411 or MN-166) is an anti-inflammatory drug used mainly in Japan, which acts as a phosphodiesterase inhibitor, inhibiting the PDE4 subtype to the greatest extent,^[1] but also showing significant inhibition of other PDE subtypes.^[2]^[3]

^ Huang Z, Liu S, Zhang L, Salem M, Greig GM, Chan CC, et al. (May 2006). "Preferential inhibition of human phosphodiesterase 4 by ibudilast". Life Sciences. 78 (23): 2663–2668. doi:10.1016/j.lfs.2005.10.026. PMID 16313925.
^ Suzumura A, Ito A, Yoshikawa M, Sawada M (August 1999). "Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS". Brain Research. 837 (1–2): 203–212. doi:10.1016/s0006-8993(99)01666-2. PMID 10434004. S2CID 7910607.
^ Gibson LC, Hastings SF, McPhee I, Clayton RA, Darroch CE, Mackenzie A, et al. (May 2006). "The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family". European Journal of Pharmacology. 538 (1–3): 39–42. doi:10.1016/j.ejphar.2006.02.053. PMID 16674936.

[1] Huang Z, Liu S, Zhang L, Salem M, Greig GM, Chan CC, et al. (May 2006). "Preferential inhibition of human phosphodiesterase 4 by ibudilast". Life Sciences. 78 (23): 2663–2668. doi:10.1016/j.lfs.2005.10.026. PMID 16313925.

[2] Suzumura A, Ito A, Yoshikawa M, Sawada M (August 1999). "Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS". Brain Research. 837 (1–2): 203–212. doi:10.1016/s0006-8993(99)01666-2. PMID 10434004. S2CID 7910607.

[3] Gibson LC, Hastings SF, McPhee I, Clayton RA, Darroch CE, Mackenzie A, et al. (May 2006). "The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family". European Journal of Pharmacology. 538 (1–3): 39–42. doi:10.1016/j.ejphar.2006.02.053. PMID 16674936.

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