Clinical data | |
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Other names | Iododeoxyuridine; IUdR |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a601062 |
Pregnancy category |
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Routes of administration | topically |
ATC code | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.189 |
Chemical and physical data | |
Formula | C9H11IN2O5 |
Molar mass | 354.100 g·mol−1 |
3D model (JSmol) | |
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(what is this?) (verify) |
Idoxuridine is an anti-herpesvirus antiviral drug.
It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing. It is used only topically due to cardiotoxicity. It was synthesized by William Prusoff in the late 1950s.[1] Initially developed as an anticancer drug, idoxuridine became the first antiviral agent in 1962.[2]
Prusoff
was invoked but never defined (see the help page).