Iloperidone

Iloperidone
Clinical data
Trade names	Fanapt, Zomaril
AHFS/Drugs.com	Monograph
MedlinePlus	a609026
License data	US DailyMed: Iloperidone; US FDA: Iloperidone;
Routes of; administration	Oral, injection
Drug class	Atypical antipsychotic
ATC code	N05AX14 (WHO) ;
Legal status
Legal status	US: WARNINGRx-only;
Pharmacokinetic data
Bioavailability	96% (oral; Tmax = 2–4 hours)
Protein binding	~97%
Metabolism	Hepatic (CYP2D6-mediated hydroxylation and CYP3A4-mediated O-demethylation)
Elimination half-life	18–33 hours
Excretion	urine (45.1–58.2%) and feces (19.9–22.1%)
Identifiers
	IUPAC name 1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone;
CAS Number	133454-47-4 ;
PubChem CID	71360;
IUPHAR/BPS	87;
ChemSpider	64459 ;
UNII	VPO7KJ050N;
KEGG	D02666 ;
ChEBI	CHEBI:65173 ;
ChEMBL	ChEMBL14376 ;
CompTox Dashboard (EPA)	DTXSID6049060 ;
ECHA InfoCard	100.106.441
Chemical and physical data
Formula	C24H27FN2O4
Molar mass	426.488 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c4ccc(OCCCN3CCC(c2noc1cc(F)ccc12)CC3)c(OC)c4)C;
	InChI InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3 ; Key:XMXHEBAFVSFQEX-UHFFFAOYSA-N ;
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Iloperidone, commonly known as Fanapt and previously known as Zomaril, is an atypical antipsychotic for the treatment of schizophrenia and bipolar I disorder.