Imine reductase

SkIRED
Streptomyces kanamyceticus R-selective imine reductase PDB: 3ZHB​
Identifiers
EC no.1.5.1.48
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

An imine reductase (IRED) is an enzyme that reduces imines to amines.[1][2] This family of enzymes is employed in the industrial production of amine-containing pharmaceuticals.[3] The IRED enzymes that are found to catalyze both imine formation and imine reduction are called reductive aminases (RedAms).

  1. ^ Mangas-Sanchez J, France SP, Montgomery SL, Aleku GA, Man H, Sharma M, et al. (April 2017). "Imine reductases (IREDs)". Current Opinion in Chemical Biology. 37: 19–25. doi:10.1016/j.cbpa.2016.11.022. PMID 28038349.
  2. ^ Lenz M, Borlinghaus N, Weinmann L, Nestl BM (October 2017). "Recent advances in imine reductase-catalyzed reactions". World Journal of Microbiology & Biotechnology. 33 (11): 199. doi:10.1007/s11274-017-2365-8. PMID 29022156. S2CID 255141416.
  3. ^ Gilio AK, Thorpe TW, Turner N, Grogan G (May 2022). "Reductive aminations by imine reductases: from milligrams to tons". Chemical Science. 13 (17): 4697–4713. doi:10.1039/D2SC00124A. PMC 9067572. PMID 35655886.