Main staining patterns on chromogenic immunohistochemistry.Immunofluorescence of human skin using an anti-IgA antibody. The skin is from a patient with Henoch–Schönlein purpura: IgA deposits are found in the walls of small superficial capillaries (yellow arrows). The pale wavy green area on top is the epidermis, the bottom fibrous area is the dermis."Block" staining: strong nuclear and cytoplasmic expression in a continuous segment of cells.[1]
Immunohistochemical staining is widely used in the diagnosis of abnormal cells such as those found in cancerous tumors. In some cancer cells certain tumor antigens are expressed which make it possible to detect. Immunohistochemistry is also widely used in basic research, to understand the distribution and localization of biomarkers and differentially expressed proteins in different parts of a biological tissue.[4]
^Image by Mikael Häggström, MD. Reference for terminology: Anjelica Hodgson, M.D., Carlos Parra-Herran, M.D. "p16". Pathology Outlines.{{cite web}}: CS1 maint: multiple names: authors list (link) Last staff update: 25 January 2024