Inhaled ciclosporin

Ciclosporin is a cyclic polypeptide that has been used widely as an orally-available immunosuppressant.[1] It was originally used to prevent transplant rejection of solid organs but has also found use as an orally administered agent to treat psoriasis,[2] rheumatoid arthritis,[3] dry eye[4] and other auto-immune related conditions. A variety of pre-clinical and clinical studies have been and are investigating its use to treat lung-related disorders via inhalation.

  1. ^ Calne, R (Mar 2004). "Cyclosporine as a milestone in immunosuppression". Transplant. Proc. 36 (2 Suppl): 13S–15S. doi:10.1016/j.transproceed.2004.01.042. PMID 15041300.
  2. ^ Madan V, Griffiths CE. "Systemic ciclosporin and tacrolimus in dermatology. Dermatol Ther. 2007 Jul-Aug;20(4):239-50.
  3. ^ Kitahara K, Kawai S. "Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis. Curr Opin Rheumatol. 2007 May;19(3):238-45. Review.
  4. ^ Ridder, WH 3rd (Dec 2008). "Ciclosporin use in dry eye disease patients". Expert Opin Pharmacother. 9 (17): 3121–8. doi:10.1517/14656560802500613. PMID 19006483. S2CID 72181779.{{cite journal}}: CS1 maint: numeric names: authors list (link)