Insulin-like growth factor 2

IGF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KR3, 1IGL, 2L29, 2V5P, 3E4Z
Identifiers
Aliases	IGF2, C11orf43, GRDF, IGF-II, PP9974, insulin like growth factor 2, SRS3
External IDs	OMIM: 147470; MGI: 96434; HomoloGene: 510; GeneCards: IGF2; OMA:IGF2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 2,129,112 bp[1] End 2,158,391 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 87.99 cM Start 142,204,503 bp[2] End 142,220,553 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta sural nerve stromal cell of endometrium right lobe of liver apex of heart left uterine tube muscle of thigh right uterine tube canal of the cervix left ventricle Top expressed in extraembryonic membrane yolk sac genital tubercle placenta tail of embryo neural tube dentate gyrus of hippocampal formation granule cell intra-embryonic coelom rhombencephalon mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin receptor binding hormone activity protein binding growth factor activity insulin-like growth factor receptor binding integrin binding protein serine/threonine kinase activator activity receptor ligand activity Cellular component extracellular region platelet alpha granule lumen extracellular space Biological process regulation of gene expression by genetic imprinting skeletal system development insulin receptor signaling pathway positive regulation of protein kinase B signaling regulation of transcription, DNA-templated ossification platelet degranulation multicellular organism development glucose metabolic process positive regulation of mitotic nuclear division positive regulation of cell division positive regulation of MAPK cascade positive regulation of activated T cell proliferation positive regulation of protein serine/threonine kinase activity carbohydrate metabolic process regulation of signaling receptor activity negative regulation of transcription by RNA polymerase II osteoblast differentiation in utero embryonic development embryonic placenta development positive regulation of protein phosphorylation positive regulation of cell population proliferation animal organ morphogenesis exocrine pancreas development regulation of histone modification insulin receptor signaling pathway via phosphatidylinositol 3-kinase positive regulation of multicellular organism growth positive regulation of catalytic activity positive regulation of glycogen biosynthetic process positive regulation of transcription by RNA polymerase II positive regulation of insulin receptor signaling pathway positive regulation of peptidyl-tyrosine phosphorylation striated muscle cell differentiation regulation of muscle cell differentiation embryonic placenta morphogenesis positive regulation of glycogen (starch) synthase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3481 16002 Ensembl ENSG00000167244 ENSMUSG00000048583 UniProt P01344 P09535 RefSeq (mRNA) NM_001291862 NM_000612 NM_001007139 NM_001127598 NM_001291861 NM_001122736 NM_001122737 NM_010514 NM_001315488 NM_001315489 RefSeq (protein) NP_000603 NP_001007140 NP_001121070 NP_001278790 NP_001278791 NP_001116208 NP_001116209 NP_001302417 NP_001302418 NP_034644 Location (UCSC) Chr 11: 2.13 – 2.16 Mb Chr 7: 142.2 – 142.22 Mb PubMed search [3] [4]
Wikidata
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Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on somatotropin. It is believed to be a major fetal growth factor in contrast to insulin-like growth factor 1 (IGF-1), which is a major growth factor in adults."^[5]