Insulin detemir

Insulin detemir
Clinical data
Trade namesLevemir
AHFS/Drugs.comMonograph
MedlinePlusa606012
License data
Pregnancy
category
  • AU: A
Routes of
administration		Subcutaneous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability60% (when administered s.c.)
Elimination half-life5–7 hours
Identifiers
CAS Number
DrugBank
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC267H402N64O76S6
Molar mass5916.89 g·mol−1
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Insulin detemir, sold under the brand name Levemir among others, is a long-acting modified form of medical insulin used to treat both type 1 and type 2 diabetes.[6] It is used by injection under the skin.[6] It is effective for up to 24 hours.[6]

Common side effects include low blood sugar, allergic reactions, pain at the site of injection, and weight gain.[6] Use in pregnancy and breastfeeding appears safe.[7] It works by increasing the amount of glucose that tissues take in and decreasing the amount of glucose made by the liver.[6]

Insulin detemir was approved for medical use in the European Union in June 2004, and in the United States in June 2005.[5][6][8] It is on the World Health Organization's List of Essential Medicines.[9] In 2021, it was the 117th most commonly prescribed medication in the United States, with more than 5 million prescriptions.[10][11]

  1. ^ "Levemir FlexPen 100 units/ml solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC)". (emc). 21 May 2018. Retrieved 14 April 2020.
  2. ^ "Levemir InnoLet 100 units/ml solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC)". (emc). 21 May 2018. Retrieved 14 April 2020.
  3. ^ "Levemir Penfill 100 units/ml solution for injection in cartridge - Summary of Product Characteristics (SmPC)". (emc). 21 May 2018. Retrieved 14 April 2020.
  4. ^ "Levemir- insulin detemir injection, solution". DailyMed. 24 March 2020. Retrieved 19 October 2020.
  5. ^ a b "Levemir EPAR". European Medicines Agency (EMA). Retrieved 14 April 2020.
  6. ^ a b c d e f "Insulin Detemir Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  7. ^ "Insulin detemir (Levemir) Use During Pregnancy". Drugs.com. 12 June 2019. Retrieved 14 April 2020.
  8. ^ "Drug Approval Package: Levemir Insulin Detemir[rDNA origin] Injection; NDA #021536". U.S. Food and Drug Administration (FDA). 26 July 2005. Retrieved 14 April 2020.
  9. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  10. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  11. ^ "Insulin Detemir - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.