Integrin alpha 7

ITGA7
Identifiers
Aliases	ITGA7, integrin subunit alpha 7
External IDs	OMIM: 600536; MGI: 102700; HomoloGene: 37592; GeneCards: ITGA7; OMA:ITGA7 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	55,716,404 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,794,151 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right coronary artery; ; Descending thoracic aorta; ; right auricle; ; ascending aorta; ; saphenous vein; ; popliteal artery; ; tibial arteries; ; left ventricle; ; left coronary artery;
	Top expressed in
	lumbar spinal ganglion; ; muscle of thigh; ; ankle; ; outer renal medulla; ; inner stripe of outer renal medulla; ; external carotid artery; ; lip; ; striated muscle tissue; ; skeletal muscle tissue; ; myocardium of ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	integral component of membrane; cell surface; integrin complex; plasma membrane; membrane;
Biological process	integrin-mediated signaling pathway; heterotypic cell-cell adhesion; muscle organ development; cell-matrix adhesion; extracellular matrix organization; cell adhesion; endodermal cell differentiation; regulation of cell shape;
	Sources:Amigo / QuickGO
Orthologs
	3679
	16404
	ENSG00000135424
	ENSMUSG00000025348
	Q13683
	Q61738
NM_001144996; NM_001144997; NM_002206; NM_001367993; NM_001367994;
	NM_001374465
	NM_008398; NM_001330160
NP_001138468; NP_001138469; NP_002197; NP_001354922; NP_001354923;
	NP_001361394
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene.^[5]^[6] Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7 integrin is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. Mutations in ITGA7 have been associated with congenital myopathies and noncompaction cardiomyopathy, and altered expression levels of alpha-7 integrin have been identified in various forms of muscular dystrophy.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135424 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025348 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang W, Wu W, Desai T, Ward DC, Kaufman SJ (Aug 1995). "Localization of the alpha 7 integrin gene (ITGA7) on human chromosome 12q13: clustering of integrin and Hox genes implies parallel evolution of these gene families". Genomics. 26 (3): 568–70. doi:10.1016/0888-7543(95)80176-M. PMID 7607681.
^ "Entrez Gene: ITGA7 integrin, alpha 7".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135424 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025348 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7607681-5] Wang W, Wu W, Desai T, Ward DC, Kaufman SJ (Aug 1995). "Localization of the alpha 7 integrin gene (ITGA7) on human chromosome 12q13: clustering of integrin and Hox genes implies parallel evolution of these gene families". Genomics. 26 (3): 568–70. doi:10.1016/0888-7543(95)80176-M. PMID 7607681.

[entrez-6] "Entrez Gene: ITGA7 integrin, alpha 7".

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