Integrin alpha V

ITGAV
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9
Identifiers
Aliases	ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V
External IDs	OMIM: 193210; MGI: 96608; HomoloGene: 20510; GeneCards: ITGAV; OMA:ITGAV - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	186,680,901 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	83,637,260 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; Epithelium of choroid plexus; ; germinal epithelium; ; tibia; ; right ventricle; ; skin of hip; ; visceral pleura; ; glomerulus; ; metanephric glomerulus; ; parietal pleura;
	Top expressed in
	cumulus cell; ; retinal pigment epithelium; ; renal corpuscle; ; conjunctival fornix; ; decidua; ; calvaria; ; epithelium of lens; ; body of femur; ; gastrula; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transforming growth factor beta binding; metal ion binding; voltage-gated calcium channel activity; virus receptor activity; protein kinase C binding; protease binding; extracellular matrix protein binding; extracellular matrix binding; fibronectin binding; opsonin binding; insulin-like growth factor I binding; protein binding; fibroblast growth factor binding; neuregulin binding; coreceptor activity; C-X3-C chemokine binding; signaling receptor binding; peptide binding; integrin binding;
Cellular component	lamellipodium membrane; integrin alphav-beta3 complex; extracellular exosome; alphav-beta3 integrin-IGF-1-IGF1R complex; integral component of membrane; integrin alphav-beta5 complex; membrane; integrin alphav-beta8 complex; ruffle membrane; integrin complex; microvillus membrane; filopodium membrane; external side of plasma membrane; phagocytic vesicle; plasma membrane; integral component of plasma membrane; cell surface; cytosol; focal adhesion; cell junction; specific granule membrane; integrin alphav-beta6 complex; alphav-beta3 integrin-PKCalpha complex; alphav-beta3 integrin-HMGB1 complex;
Biological process	regulation of phagocytosis; apoptotic cell clearance; endodermal cell differentiation; apolipoprotein A-I-mediated signaling pathway; negative chemotaxis; negative regulation of lipid storage; extracellular matrix organization; heterotypic cell-cell adhesion; positive regulation of cell migration; regulation of apoptotic cell clearance; substrate adhesion-dependent cell spreading; vascular endothelial growth factor receptor signaling pathway; cell-matrix adhesion; viral process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; blood vessel development; negative regulation of entry of bacterium into host cell; integrin-mediated signaling pathway; calcium ion transmembrane transport; negative regulation of macrophage derived foam cell differentiation; negative regulation of extrinsic apoptotic signaling pathway; leukocyte migration; cell-substrate adhesion; negative regulation of lipoprotein metabolic process; negative regulation of lipid transport; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of cell adhesion; ERK1 and ERK2 cascade; cell growth; positive regulation of osteoblast proliferation; cell adhesion; angiogenesis; vasculogenesis; cellular calcium ion homeostasis; positive regulation of cytosolic calcium ion concentration; positive regulation of cell population proliferation; cell migration; neutrophil degranulation; positive regulation of MAPK cascade; cell adhesion mediated by integrin; viral entry into host cell; regulation of transforming growth factor beta activation;
	Sources:Amigo / QuickGO
Orthologs
	3685
	16410
	ENSG00000138448
	ENSMUSG00000027087
	P06756
	P43406
	NM_001144999; NM_001145000; NM_002210
	NM_008402; NM_001398691
	NP_001138471; NP_001138472; NP_002201
	NP_032428; NP_001385620
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138448 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027087 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, et al. (June 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". The Journal of Clinical Investigation. 81 (6): 1993–1998. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138448 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027087 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2454952-5] Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, et al. (June 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". The Journal of Clinical Investigation. 81 (6): 1993–1998. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.

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