Integrin beta 7

ITGB7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BRQ, 3V4P, 3V4V
Identifiers
Aliases	ITGB7, integrin subunit beta 7
External IDs	OMIM: 147559; MGI: 96616; HomoloGene: 20247; GeneCards: ITGB7; OMA:ITGB7 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,207,282 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,140,379 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; bone marrow cells; ; blood; ; spleen; ; cecum; ; appendix; ; mononuclear cell; ; monocyte; ; trachea;
	Top expressed in
	blood; ; mesenteric lymph nodes; ; granulocyte; ; spleen; ; thymus; ; morula; ; morula; ; corneal stroma; ; bone marrow; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; metal ion binding; protein binding; cell adhesion molecule binding; integrin binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; receptor complex; plasma membrane; cell surface; integrin complex; extracellular exosome; integrin alpha4-beta7 complex; focal adhesion;
Biological process	T cell migration; heterotypic cell-cell adhesion; cell-matrix adhesion involved in ameboidal cell migration; extracellular matrix organization; receptor clustering; cell adhesion; regulation of immune response; leukocyte tethering or rolling; integrin-mediated signaling pathway; viral entry into host cell; substrate adhesion-dependent cell spreading; cell-matrix adhesion; leukocyte migration; cell migration; cell adhesion mediated by integrin;
	Sources:Amigo / QuickGO
Orthologs
	3695
	16421
	ENSG00000139626
	ENSMUSG00000001281
	P26010
	P26011
	NM_000889
	NM_013566
	NP_000880
	NP_038594
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.^[5]^[6] It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α₄β₇, or with ITGAE (CD103) to form α_Eβ₇.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139626 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001281 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Erle DJ, Rüegg C, Sheppard D, Pytela R (Jun 1991). "Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes". The Journal of Biological Chemistry. 266 (17): 11009–16. doi:10.1016/S0021-9258(18)99120-9. PMID 2040616.
^ "Entrez Gene: ITGB7 integrin, beta 7".
^ Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (Nov 2009). "Anti-integrin monoclonal antibodies". Journal of Cell Science. 122 (Pt 22): 4009–11. doi:10.1242/jcs.056770. PMC 3329622. PMID 19910492.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139626 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001281 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2040616-5] Erle DJ, Rüegg C, Sheppard D, Pytela R (Jun 1991). "Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes". The Journal of Biological Chemistry. 266 (17): 11009–16. doi:10.1016/S0021-9258(18)99120-9. PMID 2040616.

[entrez-6] "Entrez Gene: ITGB7 integrin, beta 7".

[pmid19910492-7] Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (Nov 2009). "Anti-integrin monoclonal antibodies". Journal of Cell Science. 122 (Pt 22): 4009–11. doi:10.1242/jcs.056770. PMC 3329622. PMID 19910492.

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