| interferon (alpha, beta and omega) receptor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IFNAR1 | ||||||
| Alt. symbols | IFNAR | ||||||
| NCBI gene | 3454 | ||||||
| HGNC | 5432 | ||||||
| OMIM | 107450 | ||||||
| RefSeq | NM_000629 | ||||||
| UniProt | P17181 | ||||||
| Other data | |||||||
| Locus | Chr. 21 q22.1 | ||||||
| |||||||
| interferon (alpha, beta and omega) receptor 2 | |||||||
|---|---|---|---|---|---|---|---|
 NMR structure of the interferon-binding ectodomain of the human interferon receptor.[1] | |||||||
| Identifiers | |||||||
| Symbol | IFNAR2 | ||||||
| Alt. symbols | IFNABR | ||||||
| NCBI gene | 3455 | ||||||
| HGNC | 5433 | ||||||
| OMIM | 602376 | ||||||
| RefSeq | NM_207585 | ||||||
| UniProt | P48551 | ||||||
| Other data | |||||||
| Locus | Chr. 21 q22.1 | ||||||
| |||||||
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human type I IFNs include many subtypes, such as interferons-α, -β, -ε, -κ, -ω, and -ζ.[2]
- ^ PDB: 1n6u; Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J (July 2003). "The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding". Structure. 11 (7): 791–802. doi:10.1016/S0969-2126(03)00120-5. PMID 12842042.
- ^ de Weerd NA, Nguyen T (May 2012). "The interferons and their receptors—distribution and regulation". Immunology and Cell Biology. 90 (5): 483–91. doi:10.1038/icb.2012.9. PMC 7165917. PMID 22410872.