Interferon-gamma receptor

interferon gamma receptor 1
Crystallographic structure of a 3:2 complex of the IFN-γ receptor alpha chain (IFNGR1) (green, cyan, and green/cyan) and the IFN-γ ligand (red and orange).[1]
Identifiers
SymbolIFNGR1
Alt. symbolsIFNGR
NCBI gene3459
HGNC5439
OMIM107470
RefSeqNM_000416
UniProtP15260
Other data
LocusChr. 6 q23-q24
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StructuresSwiss-model
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interferon gamma receptor 2 (interferon gamma transducer 1)
Identifiers
SymbolIFNGR2
Alt. symbolsIFNGT1
NCBI gene3460
HGNC5440
OMIM147569
RefSeqNM_005534
UniProtP38484
Other data
LocusChr. 21 q22.1
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StructuresSwiss-model
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The interferon-gamma receptor (IFNGR) protein complex is the heterodimer of two chains: IFNGR1 and IFNGR2. It binds interferon-γ, the sole member of interferon type II.

  1. ^ PDB: 1FG9​; Thiel DJ, le Du MH, Walter RL, D'Arcy A, Chène C, Fountoulakis M, Garotta G, Winkler FK, Ealick SE (September 2000). "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex". Structure. 8 (9): 927–36. doi:10.1016/S0969-2126(00)00184-2. PMID 10986460.