Interferon beta-1a

Interferon beta-1a
Clinical data
Trade namesAvonex, Rebif, Plegridy, others
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa604005
License data
Pregnancy
category
  • AU: D
Routes of
administration		Subcutaneous, intramuscular
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life10 hrs
Identifiers
  • Human interferon beta
CAS Number
IUPHAR/BPS
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC908H1408N246O252S7
Molar mass20027.14 g·mol−1
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Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS).[5] It is produced by mammalian cells, while interferon beta-1b is produced in modified E. coli.[6] Some research indicates that interferon injections may result in an 18–38% reduction in the rate of MS relapses.[7]

Interferon beta has not been shown to slow the advance of disability.[8][9][10][11] Interferons are not a cure for MS (there is no known cure); the claim is that interferons may slow the progress of the disease if started early and continued for the duration of the disease.[12]

  1. ^ Cite error: The named reference Avonex FDA label was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference Rebif FDA label was invoked but never defined (see the help page).
  3. ^ "Avonex EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 26 October 2020. Retrieved 1 October 2020.
  4. ^ "Rebif EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 11 November 2020. Retrieved 1 October 2020.
  5. ^ Murdoch D, Lyseng-Williamson KA (2005). "Spotlight on subcutaneous recombinant interferon-beta-1a (Rebif) in relapsing-remitting multiple sclerosis". BioDrugs. 19 (5): 323–325. doi:10.2165/00063030-200519050-00005. PMID 16207073. S2CID 3122427.
  6. ^ Giovannoni G, Munschauer FE, Deisenhammer F (November 2002). "Neutralising antibodies to interferon beta during the treatment of multiple sclerosis". Journal of Neurology, Neurosurgery, and Psychiatry. 73 (5): 465–469. doi:10.1136/jnnp.73.5.465. PMC 1738139. PMID 12397132.
  7. ^ Stachowiak J (2008). "Is Avonex Right for You?". Archived from the original on 2016-03-03. Retrieved 2008-05-07.
  8. ^ Shirani A, Zhao Y, Karim ME, Evans C, Kingwell E, van der Kop ML, et al. (July 2012). "Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis". JAMA. 308 (3): 247–256. doi:10.1001/jama.2012.7625. PMID 22797642.
  9. ^ Kappos L, Kuhle J, Multanen J, Kremenchutzky M, Verdun di Cantogno E, Cornelisse P, et al. (November 2015). "Factors influencing long-term outcomes in relapsing-remitting multiple sclerosis: PRISMS-15". Journal of Neurology, Neurosurgery, and Psychiatry. 86 (11): 1202–1207. doi:10.1136/jnnp-2014-310024. PMC 4680156. PMID 26374702.
  10. ^ Calabresi PA, Kieseier BC, Arnold DL, Balcer LJ, Boyko A, Pelletier J, et al. (July 2014). "Pegylated interferon β-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study". The Lancet. Neurology. 13 (7): 657–665. doi:10.1016/S1474-4422(14)70068-7. PMID 24794721. S2CID 45183415.
  11. ^ Jacobs LD, Cookfair DL, Rudick RA, Herndon RM, Richert JR, Salazar AM, et al. (March 1996). "Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)". Annals of Neurology. 39 (3): 285–294. doi:10.1002/ana.410390304. PMID 8602746. S2CID 24663294.
  12. ^ Cite error: The named reference pmid21205679 was invoked but never defined (see the help page).