Interferon gamma receptor 1

IFNGR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FG9, 1FYH, 1JRH
Identifiers
Aliases	IFNGR1, CD119, IFNGR, IMD27A, IMD27B, interferon gamma receptor 1
External IDs	OMIM: 107470; MGI: 107655; HomoloGene: 359; GeneCards: IFNGR1; OMA:IFNGR1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	137,219,449 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	19,485,977 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; epithelium of nasopharynx; ; right lung; ; jejunal mucosa; ; pericardium; ; human penis; ; palpebral conjunctiva; ; skin of hip; ; monocyte; ; upper lobe of lung;
	Top expressed in
	lower jaw; ; Meckel's cartilage; ; mandibular molars; ; thymus; ; left colon; ; granulocyte; ; myometrium; ; duodenum; ; tibiofemoral joint; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	interferon-gamma receptor activity; protein binding; cytokine binding; cytokine receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	response to virus; regulation of interferon-gamma-mediated signaling pathway; signal transduction; interferon-gamma-mediated signaling pathway; cytokine-mediated signaling pathway; microglial cell activation; positive regulation of gene expression; astrocyte activation; negative regulation of amyloid-beta clearance; positive regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
Orthologs
	3459
	15979
	ENSG00000027697
	ENSMUSG00000020009
	P15260
	P15261
	NM_000416; NM_001363526; NM_001363527
	NM_010511
	NP_000407; NP_001350455; NP_001350456
	NP_034641
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000027697 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020009 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IFNGR1 interferon gamma receptor 1".
^ Novick D, Orchansky P, Revel M, Rubinstein M (Jun 1987). "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies". The Journal of Biological Chemistry. 262 (18): 8483–7. doi:10.1016/S0021-9258(18)47439-X. PMID 2954953.
^ Aguet M, Dembić Z, Merlin G (Oct 1988). "Molecular cloning and expression of the human interferon-gamma receptor". Cell. 55 (2): 273–80. doi:10.1016/0092-8674(88)90050-5. PMID 2971451. S2CID 54247636.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000027697 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020009 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IFNGR1 interferon gamma receptor 1".

[pmid2954953-6] Novick D, Orchansky P, Revel M, Rubinstein M (Jun 1987). "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies". The Journal of Biological Chemistry. 262 (18): 8483–7. doi:10.1016/S0021-9258(18)47439-X. PMID 2954953.

[pmid2971451-7] Aguet M, Dembić Z, Merlin G (Oct 1988). "Molecular cloning and expression of the human interferon-gamma receptor". Cell. 55 (2): 273–80. doi:10.1016/0092-8674(88)90050-5. PMID 2971451. S2CID 54247636.

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