Interleukin-17A

IL17A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VXS, 4HR9, 4HSA, 4QHU, 5HHV, 5HHX
Identifiers
Aliases	IL17A, CTLA8, IL-17, IL-17A, IL17, CTLA-8, interleukin 17A, ILA17, Interleukin 17A
External IDs	OMIM: 603149; MGI: 107364; HomoloGene: 1651; GeneCards: IL17A; OMA:IL17A - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	52,190,638 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	20,804,720 bp
RNA expression pattern
	Top expressed in
	appendix; ; pylorus; ; palpebral conjunctiva; ; gallbladder; ; mucosa of transverse colon; ; tonsil; ; human penis; ; duodenum; ; urinary bladder; ; smooth muscle tissue;
	Top expressed in
	lumbar subsegment of spinal cord; ; tibiofemoral joint; ; CA3 field; ; gastrula; ; digastric muscle; ; right ventricle; ; submandibular gland; ; carotid body; ; lumbar spinal ganglion; ; ileum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein binding;
Cellular component	external side of plasma membrane; extracellular region; extracellular space;
Biological process	positive regulation of cytokine production involved in inflammatory response; cell-cell signaling; positive regulation of osteoclast differentiation; cell death; defense response to fungus; cellular response to interleukin-1; immune response; fibroblast activation; positive regulation of interleukin-23 production; positive regulation of transcription by RNA polymerase II; apoptotic process; inflammatory response; regulation of signaling receptor activity; cytokine-mediated signaling pathway; interleukin-17-mediated signaling pathway; granulocyte migration;
	Sources:Amigo / QuickGO
Orthologs
	3605
	16171
	ENSG00000112115
	ENSMUSG00000025929
	Q16552
	Q62386
	NM_002190
	NM_010552
	NP_002181
	NP_034682
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8, after the similarity with a viral gene (O40633).^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112115 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025929 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P (June 1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene". Journal of Immunology. 150 (12): 5445–5456. doi:10.4049/jimmunol.150.12.5445. PMID 8390535. S2CID 5802339.
^ "Entrez Gene: IL17A interleukin 17A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112115 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025929 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Rouvier_1993-5] Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P (June 1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene". Journal of Immunology. 150 (12): 5445–5456. doi:10.4049/jimmunol.150.12.5445. PMID 8390535. S2CID 5802339.

[entrez-6] "Entrez Gene: IL17A interleukin 17A".

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