Interleukin-1 receptor family

Interleukin-1 receptor
Identifiers
SymbolInterleukin-1 receptor
InterProIPR015621
Membranome13

Members of the very wide interleukin-1 receptor (IL-1R) family are characterized by extracellular immunoglobulin-like domains and intracellular Toll/Interleukin-1R (TIR) domain. It is a group of structurally homologous proteins, conserved throughout the species as it was identified from plants to mammals. Proteins of this family play important role in host defence, injury and stress.[1] There are four main groups of TIR domain-containing proteins in animals; Toll-like receptors, Interleukin-1 receptor (IL-1R), cytosolic adaptor proteins (such as MyD88 adaptor protein) and insect and nematode Toll. Each of these groups is involved mainly in host defence; Toll receptors are also involved in embryogenesis.[2]

  1. ^ Bowie A, O'Neill LA (April 2000). "The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products". Journal of Leukocyte Biology. 67 (4): 508–14. doi:10.1002/jlb.67.4.508. hdl:2262/33703. PMID 10770283.
  2. ^ Boraschi D, Tagliabue A (2006). "The interleukin-1 receptor family". Vitamins and Hormones. 74 (4): 229–54. doi:10.1016/s0083-6729(06)74009-2. ISBN 9780127098746. PMID 17027517.