Interleukin-23 receptor

IL23R
Identifiers
Aliases	IL23R, interleukin 23 receptor
External IDs	OMIM: 607562; MGI: 2181693; HomoloGene: 16930; GeneCards: IL23R; OMA:IL23R - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 67,138,907 bp[1] End 67,259,979 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C1 Start 67,399,916 bp[2] End 67,468,839 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte amniotic fluid rectum islet of Langerhans appendix epithelium of colon gallbladder right adrenal gland right adrenal cortex left adrenal gland Top expressed in zygote secondary oocyte primary oocyte embryo embryo adrenal gland thymus ileum jejunum esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function interleukin-23 receptor activity interleukin-12 receptor binding protein binding interleukin-23 binding cytokine receptor activity cytokine binding Cellular component integral component of membrane interleukin-23 receptor complex membrane receptor complex plasma membrane external side of plasma membrane Biological process negative regulation of interleukin-10 production response to interferon-gamma positive regulation of interleukin-12 production immune system process positive regulation of T cell mediated cytotoxicity positive regulation of interferon-gamma production positive regulation of osteoclast differentiation positive regulation of T-helper 17 cell lineage commitment positive regulation of NK T cell activation positive regulation of natural killer cell proliferation response to lipopolysaccharide positive regulation of T-helper 17 type immune response positive regulation of T-helper 1 type immune response positive regulation of granulocyte macrophage colony-stimulating factor production defense response to Gram-negative bacterium positive regulation of T cell proliferation positive regulation of memory T cell differentiation positive regulation of interleukin-17 production innate immune response inflammatory response positive regulation of activated T cell proliferation positive regulation of defense response to virus by host positive regulation of activation of Janus kinase activity regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein cytokine-mediated signaling pathway interleukin-23-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 149233 209590 Ensembl ENSG00000162594 ENSMUSG00000049093 UniProt Q5VWK5 Q8K4B4 RefSeq (mRNA) NM_144701 NM_144548 RefSeq (protein) NP_653302 NP_653131 Location (UCSC) Chr 1: 67.14 – 67.26 Mb Chr 6: 67.4 – 67.47 Mb PubMed search [3] [4]
Wikidata
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The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene.^[5] In complex with the interleukin-12 receptor β1 subunit (IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23).^[6] The IL23R mRNA is 2.8 kilobases in length and includes 12 exons. The translated protein contains 629 amino acids; it is a type I penetrating protein and includes a signal peptide, an N-terminal fibronectin III-like domain and an intracellular part that contains three potential tyrosine phosphorylation domains.^[6] There are 24 IL23R splice variants in mitogen-activated lymphocytes.^[7] IL23R includes some single-nucleotide polymorphisms in the region encoding the domain that binds IL-23, which may lead to differences between people in Th17 activation.^[8] There is also a variant of IL-23R that consists of just the extracellular part and is known as soluble IL-23R. This form can compete with the membrane-bound form to bind IL-23, modulating the Th17 immune response and regulation of inflammation and immune function.^[9]