Interleukin-23 receptor

IL23R
Identifiers
AliasesIL23R, interleukin 23 receptor
External IDsOMIM: 607562; MGI: 2181693; HomoloGene: 16930; GeneCards: IL23R; OMA:IL23R - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144701

NM_144548

RefSeq (protein)

NP_653302

NP_653131

Location (UCSC)Chr 1: 67.14 – 67.26 MbChr 6: 67.4 – 67.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene.[5] In complex with the interleukin-12 receptor β1 subunit (IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23).[6] The IL23R mRNA is 2.8 kilobases in length and includes 12 exons. The translated protein contains 629 amino acids; it is a type I penetrating protein and includes a signal peptide, an N-terminal fibronectin III-like domain and an intracellular part that contains three potential tyrosine phosphorylation domains.[6] There are 24 IL23R splice variants in mitogen-activated lymphocytes.[7] IL23R includes some single-nucleotide polymorphisms in the region encoding the domain that binds IL-23, which may lead to differences between people in Th17 activation.[8] There is also a variant of IL-23R that consists of just the extracellular part and is known as soluble IL-23R. This form can compete with the membrane-bound form to bind IL-23, modulating the Th17 immune response and regulation of inflammation and immune function.[9]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162594Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049093Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: IL23R interleukin 23 receptor".
  6. ^ a b Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. (June 2002). "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R". Journal of Immunology. 168 (11): 5699–708. doi:10.4049/jimmunol.168.11.5699. PMID 12023369.
  7. ^ Kan SH, Mancini G, Gallagher G (October 2008). "Identification and characterization of multiple splice forms of the human interleukin-23 receptor alpha chain in mitogen-activated leukocytes". Genes and Immunity. 9 (7): 631–9. doi:10.1038/gene.2008.64. PMID 18754016.
  8. ^ Yu RY, Brazaitis J, Gallagher G (February 2015). "The human IL-23 receptor rs11209026 A allele promotes the expression of a soluble IL-23R-encoding mRNA species". Journal of Immunology. 194 (3): 1062–8. doi:10.4049/jimmunol.1401850. PMID 25552541.
  9. ^ "Figure 8. with two source data miR-34a regulates Th17 cell-mediated proliferation". doi:10.7554/elife.39479.025. {{cite journal}}: Cite journal requires |journal= (help)