Interleukin-5 receptor

interleukin 5 receptor, alpha
Identifiers
SymbolIL5RA
Alt. symbolsIL5R
NCBI gene3568
HGNC6017
OMIM147851
RefSeqNM_175725
UniProtQ01344
Other data
LocusChr. 3 p26-p24
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StructuresSwiss-model
DomainsInterPro
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Identifiers
SymbolCSF2RB
Alt. symbolsIL3RB
NCBI gene1439
HGNC2436
OMIM138981
RefSeqNM_000395
UniProtP32927
Other data
LocusChr. 22 q12.2-13.1
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StructuresSwiss-model
DomainsInterPro

The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB.[1][2]

The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of two polypeptide chains, one α subunit, which binds IL-5 and confers upon the receptor cytokine specificity, and one β subunit, which contains the signal transduction domains.

  1. ^ Takatsu K, Tominaga A (1991). "Interleukin 5 and its receptor". Prog. Growth Factor Res. 3 (2): 87–102. doi:10.1016/S0955-2235(05)80001-8. PMID 1773042.
  2. ^ Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K (1992). "Molecular cloning and expression of the human interleukin 5 receptor". J. Exp. Med. 175 (2): 341–51. doi:10.1084/jem.175.2.341. PMC 2119102. PMID 1732409.