Interleukin 10

IL10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24
Identifiers
Aliases	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10
External IDs	OMIM: 124092; MGI: 96537; HomoloGene: 478; GeneCards: IL10; OMA:IL10 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 206,767,602 bp[1] End 206,774,541 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 56.89 cM Start 130,947,582 bp[2] End 130,952,711 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix gallbladder cartilage tissue spleen left uterine tube lymph node gastric mucosa right adrenal cortex left adrenal cortex granulocyte Top expressed in embryo embryo lumbar subsegment of spinal cord stroma of bone marrow entorhinal cortex epiblast lumbar spinal ganglion thymus tracheobronchial tree stria vascularis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding growth factor activity cytokine activity interleukin-10 receptor binding protein dimerization activity Cellular component extracellular region extracellular space Biological process negative regulation of chronic inflammatory response to antigenic stimulus positive regulation of MHC class II biosynthetic process negative regulation of endothelial cell apoptotic process hemopoiesis negative regulation of interferon-gamma production regulation of sensory perception of pain positive regulation of B cell apoptotic process negative regulation of chemokine (C-C motif) ligand 5 production response to inactivity negative regulation of cytokine activity negative regulation of interleukin-1 production cellular response to hepatocyte growth factor stimulus cellular response to estradiol stimulus negative regulation of interleukin-6 production ageing positive regulation of DNA-binding transcription factor activity negative regulation of apoptotic process negative regulation of cytokine production involved in immune response response to glucocorticoid cytoplasmic sequestering of NF-kappaB negative regulation of interleukin-18 production negative regulation of MHC class II biosynthetic process response to activity response to organic substance response to carbon monoxide leukocyte chemotaxis type 2 immune response negative regulation of myeloid dendritic cell activation response to insulin negative regulation of interleukin-8 production response to lipopolysaccharide B cell proliferation negative regulation of T cell proliferation negative regulation of nitric oxide biosynthetic process branching involved in labyrinthine layer morphogenesis defense response to bacterium regulation of complement-dependent cytotoxicity immune response regulation of gene expression B cell differentiation regulation of isotype switching negative regulation of tumor necrosis factor production negative regulation of membrane protein ectodomain proteolysis inflammatory response cellular response to lipopolysaccharide negative regulation of B cell proliferation negative regulation of inflammatory response negative regulation of cytokine production positive regulation of transcription by RNA polymerase II negative regulation of interleukin-12 production defense response to protozoan negative regulation of sensory perception of pain positive regulation of macrophage activation liver regeneration regulation of synapse organization positive regulation of endothelial cell proliferation negative regulation of cell population proliferation negative regulation of heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion positive regulation of cell cycle negative regulation of mitotic cell cycle endothelial cell apoptotic process regulation of response to wounding negative regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation interleukin-12-mediated signaling pathway positive regulation of transcription, DNA-templated negative regulation of autophagy cytokine-mediated signaling pathway positive regulation of receptor signaling pathway via JAK-STAT positive regulation of pri-miRNA transcription by RNA polymerase II negative regulation of hydrogen peroxide-induced neuron death positive regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3586 16153 Ensembl ENSG00000136634 ENSMUSG00000016529 UniProt P22301 P18893 RefSeq (mRNA) NM_000572 NM_010548 RefSeq (protein) NP_000563 NP_034678 Location (UCSC) Chr 1: 206.77 – 206.77 Mb Chr 1: 130.95 – 130.95 Mb PubMed search [3] [4]
Wikidata
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Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene.^[5] IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins.^[6] Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively.^[6]