Interleukin 15

IL15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XQB, 2Z3Q, 2Z3R, 4GS7
Identifiers
Aliases	IL15, IL-15, interleukin 15
External IDs	OMIM: 600554; MGI: 103014; HomoloGene: 487; GeneCards: IL15; OMA:IL15 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.21 Start 141,636,583 bp[1] End 141,733,987 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C2|8 39.33 cM Start 83,058,261 bp[2] End 83,129,851 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua monocyte stromal cell of endometrium left lobe of thyroid gland granulocyte right lobe of thyroid gland spleen Descending thoracic aorta gastric mucosa ascending aorta Top expressed in granulocyte right ventricle cardiac muscles right kidney myocardium of ventricle embryo duodenum cardiac muscle tissue of left ventricle proximal tubule seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cytokine receptor binding cytokine activity Cellular component nucleus integral component of plasma membrane Golgi apparatus endosome nucleoplasm membrane cell surface extracellular region extracellular space cytoplasm cytosol nuclear speck Biological process negative regulation of smooth muscle cell proliferation cell maturation extrathymic T cell selection positive regulation of T cell proliferation regulation of defense response to virus by host positive regulation of inflammatory response response to nutrient levels positive regulation of protein O-linked glycosylation positive regulation of interleukin-17 production hyaluronan metabolic process positive regulation of natural killer cell differentiation regulation of T cell differentiation positive regulation of tissue remodeling cellular response to vitamin D lymph node development natural killer cell differentiation positive regulation of natural killer cell proliferation cell-cell signaling skeletal muscle atrophy signal transduction ageing NK T cell proliferation positive regulation of immune response inflammatory response immune response positive regulation of cell population proliferation tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein regulation of signaling receptor activity interleukin-15-mediated signaling pathway neutrophil activation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis negative regulation of cold-induced thermogenesis macrophage differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3600 16168 Ensembl ENSG00000164136 ENSMUSG00000031712 UniProt P40933 P48346 RefSeq (mRNA) NM_000585 NM_172174 NM_172175 NM_001254747 NM_008357 RefSeq (protein) NP_000576 NP_751915 NP_001241676 NP_032383 Location (UCSC) Chr 4: 141.64 – 141.73 Mb Chr 8: 83.06 – 83.13 Mb PubMed search [3] [4]
Wikidata
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Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces the proliferation of natural killer cells, i.e. cells of the innate immune system whose principal role is to kill virally infected cells.