Interleukin 2

IL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IRL, 1M47, 1M48, 1M49, 1M4A, 1M4B, 1M4C, 1NBP, 1PW6, 1PY2, 1QVN, 1Z92, 2B5I, 2ERJ, 3QAZ, 3QB1, 3INK, 4NEJ, 4NEM
Identifiers
Aliases	IL2, IL-2, TCGF, lymphokine, interleukin 2
External IDs	OMIM: 147680; MGI: 96548; HomoloGene: 488; GeneCards: IL2; OMA:IL2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q27 Start 122,451,470 bp[1] End 122,456,725 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 B|3 18.3 cM Start 37,174,672 bp[2] End 37,180,108 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle lymph node appendix granulocyte rectum duodenum gallbladder spleen right lung Top expressed in pharynx spermatid ganglionic eminence duodenum esophagus foregut stomach blastocyst spermatocyte ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity interleukin-2 receptor binding glycosphingolipid binding kinase activator activity growth factor activity kappa-type opioid receptor binding carbohydrate binding protein binding Cellular component extracellular region intracellular anatomical structure extracellular space Biological process positive regulation of T cell differentiation negative regulation of protein phosphorylation G protein-coupled receptor signaling pathway positive regulation of protein phosphorylation positive regulation of inflammatory response adaptive immune response negative regulation of heart contraction immune system process positive regulation of cytosolic calcium ion concentration positive regulation of regulatory T cell differentiation cell-cell signaling positive regulation of interferon-gamma production natural killer cell activation negative regulation of apoptotic process positive regulation of dendritic spine development negative regulation of lymphocyte proliferation MAPK cascade regulation of T cell homeostatic proliferation T cell differentiation positive regulation of cell growth protein kinase C-activating G protein-coupled receptor signaling pathway cell adhesion positive regulation of B cell proliferation positive regulation of tissue remodeling positive regulation of T cell proliferation immune response positive regulation of cell population proliferation extrinsic apoptotic signaling pathway in absence of ligand negative regulation of B cell apoptotic process positive regulation of isotype switching to IgG isotypes positive regulation of interleukin-17 production response to ethanol negative regulation of inflammatory response positive regulation of transcription by RNA polymerase II positive regulation of activated T cell proliferation negative regulation of T-helper 17 cell differentiation leukocyte activation involved in immune response positive regulation of tyrosine phosphorylation of STAT protein regulation of regulatory T cell differentiation regulation of signaling receptor activity cytokine-mediated signaling pathway interleukin-2-mediated signaling pathway positive regulation of kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3558 16183 Ensembl ENSG00000109471 ENSMUSG00000027720 UniProt P60568 P04351 RefSeq (mRNA) NM_000586 NM_008366 RefSeq (protein) NP_000577 NP_032392 Location (UCSC) Chr 4: 122.45 – 122.46 Mb Chr 3: 37.17 – 37.18 Mb PubMed search [3] [4]
Wikidata
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Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein^[5] that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes. The major sources of IL-2 are activated CD4⁺ T cells and activated CD8⁺ T cells.^[6] Put shortly the function of IL-2 is to stimulate the growth of helper, cytotoxic and regulatory T cells.