Protein-coding gene in the species Homo sapiens
Interleukin 20 receptor , beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor . It is believed to be involved in both pro-inflammatory and anti-inflammatory responses.[ 5] [ 6]
IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis , osteoclasts , found in bones, and epithelial cells of the intestine and trachea . IL20RB is also found in some immune cells.[ 7] The subunit has been linked with multiple diseases, including gastrointestinal diseases and glaucoma.
^ a b c GRCh38: Ensembl release 89: ENSG00000174564 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044244 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Rutz S, Wang X, Ouyang W (December 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology . 14 (12): 783–795. doi :10.1038/nri3766 . PMID 25421700 . S2CID 29114703 .
^ Wegenka UM (October 2010). "IL-20: biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews . 21 (5): 353–363. doi :10.1016/j.cytogfr.2010.08.001 . PMID 20864382 .
^ Kragstrup TW, Andersen T, Heftdal LD, Hvid M, Gerwien J, Sivakumar P, et al. (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis" . Frontiers in Immunology . 9 : 2226. doi :10.3389/fimmu.2018.02226 . PMC 6167463 . PMID 30319661 .