Interleukin 20 receptor, beta subunit

IL20RB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL20RB, DIRS1, FNDC6, IL-20R2, Interleukin 20 receptor, beta subunit, interleukin 20 receptor subunit beta
External IDsOMIM: 605621; MGI: 2143266; HomoloGene: 86034; GeneCards: IL20RB; OMA:IL20RB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144717

NM_001033543
NM_001037246

RefSeq (protein)

NP_653318

NP_001028715

Location (UCSC)Chr 3: 136.95 – 137.01 MbChr 9: 100.34 – 100.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 20 receptor, beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor. It is believed to be involved in both pro-inflammatory and anti-inflammatory responses.[5][6]

IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RB is also found in some immune cells.[7] The subunit has been linked with multiple diseases, including gastrointestinal diseases and glaucoma.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174564Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044244Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rutz S, Wang X, Ouyang W (December 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology. 14 (12): 783–795. doi:10.1038/nri3766. PMID 25421700. S2CID 29114703.
  6. ^ Wegenka UM (October 2010). "IL-20: biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. PMID 20864382.
  7. ^ Kragstrup TW, Andersen T, Heftdal LD, Hvid M, Gerwien J, Sivakumar P, et al. (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9: 2226. doi:10.3389/fimmu.2018.02226. PMC 6167463. PMID 30319661.