Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene.[5][6][7]
Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.[5][8] This cytokine induces cell division/proliferation in its target cells.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138684 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027718 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D (November 2000). "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function". Nature. 408 (6808): 57–63. Bibcode:2000Natur.408...57P. doi:10.1038/35040504. PMID 11081504. S2CID 4428126.
- ^ Kuchen S, Robbins R, Sims GP, Sheng C, Phillips TM, Lipsky PE, Ettinger R (November 2007). "Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration". Journal of Immunology. 179 (9): 5886–96. doi:10.4049/jimmunol.179.9.5886. PMID 17947662.
- ^ "Entrez Gene: IL21 interleukin 21".
- ^ Parrish-Novak J, Foster DC, Holly RD, Clegg CH (November 2002). "Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses". Journal of Leukocyte Biology. 72 (5): 856–63. doi:10.1189/jlb.72.5.856. PMID 12429707. S2CID 27480657.