Interleukin 22

IL22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M4R, 1YKB, 3DGC, 3DLQ, 3G9V, 3Q1S
Identifiers
Aliases	IL22, IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18, interleukin 22
External IDs	OMIM: 605330; MGI: 2151139; HomoloGene: 9669; GeneCards: IL22; OMA:IL22 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	68,253,604 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	118,130,943 bp
RNA expression pattern
	Top expressed in
	appendix; ; muscle tissue; ; granulocyte; ; mucosa of pharynx; ; epithelium of esophagus; ; thigh; ; duodenum; ; muscle of thigh; ; tonsil; ; urinary bladder;
	Top expressed in
	morula; ; primary oocyte; ; cerebellum; ; secondary oocyte; ; cerebellar cortex; ; zygote; ; blastocyst; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; mesencephalon;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; interleukin-22 receptor binding; cytokine activity;
Cellular component	extracellular space; extracellular region;
Biological process	response to glucocorticoid; acute-phase response; inflammatory response; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50616
	116849
	ENSG00000127318
	ENSMUSG00000090461
	Q9GZX6
	Q9JJY8
	NM_020525
	NM_054079
	NP_065386
	NP_473420
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-22 (IL-22) is a protein that in humans is encoded by the IL22 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127318 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090461 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dumoutier L, Van Roost E, Colau D, Renauld JC (August 2000). "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor". Proceedings of the National Academy of Sciences of the United States of America. 97 (18): 10144–9. Bibcode:2000PNAS...9710144D. doi:10.1073/pnas.170291697. PMC 27764. PMID 10954742.
^ Cite error: The named reference pmid10875937 was invoked but never defined (see the help page).