Interleukin 23 subunit alpha

IL23A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D85, 3D87, 3DUH, 3QWR, 4GRW, 4OE8, 4OG9
Identifiers
Aliases	IL23A, IL-23, IL-23A, IL23P19, P19, SGRF, Interleukin 23, interleukin 23 subunit alpha
External IDs	OMIM: 605580; MGI: 1932410; HomoloGene: 12832; GeneCards: IL23A; OMA:IL23A - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,334,174 bp[1] End 56,340,410 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,132,008 bp[2] End 128,134,621 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis pancreatic ductal cell granulocyte sperm cartilage tissue gonad oocyte oral cavity Top expressed in secondary oocyte morula zygote primary oocyte decidua atrioventricular valve optic nerve cumulus cell endocardial cushion embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity interleukin-23 receptor binding protein binding Cellular component interleukin-23 complex extracellular region extracellular space endoplasmic reticulum lumen Biological process negative regulation of interleukin-10 production positive regulation of inflammatory response positive regulation of interleukin-12 production positive regulation of interleukin-10 production immune system process positive regulation of T cell mediated cytotoxicity positive regulation of interferon-gamma production positive regulation of natural killer cell activation positive regulation of osteoclast differentiation positive regulation of T-helper 17 cell lineage commitment positive regulation of NK T cell activation T cell proliferation positive regulation of natural killer cell proliferation positive regulation of NK T cell proliferation positive regulation of T-helper 17 type immune response defense response to virus positive regulation of tissue remodeling positive regulation of T-helper 1 type immune response positive regulation of granulocyte macrophage colony-stimulating factor production defense response to Gram-negative bacterium positive regulation of T cell proliferation immune response positive regulation of memory T cell differentiation positive regulation of neutrophil chemotaxis positive regulation of tumor necrosis factor production positive regulation of interleukin-17 production innate immune response inflammatory response tissue remodeling positive regulation of transcription by RNA polymerase II positive regulation of activated T cell proliferation positive regulation of defense response to virus by host positive regulation of activation of Janus kinase activity regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein regulation of signaling receptor activity cytokine-mediated signaling pathway interleukin-23-mediated signaling pathway positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51561 83430 Ensembl ENSG00000110944 ENSMUSG00000025383 UniProt Q9NPF7 Q9EQ14 RefSeq (mRNA) NM_016584 NM_031252 RefSeq (protein) NP_057668 NP_112542 Location (UCSC) Chr 12: 56.33 – 56.34 Mb Chr 10: 128.13 – 128.13 Mb PubMed search [3] [4]
Wikidata
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Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene.^[5][6] The protein is also known as IL-23p19. It is one of the two subunits of the cytokine Interleukin-23.

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40 subunit. The IL-12p40, also known as Interleukin 12 subunit beta, is used by both IL-23 (where it partners with IL-23p19) and IL-12 (where it partners with IL-12A).^[5] A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of IL-12R β1 and IL-23R.^[7]