Interleukin 27 receptor, alpha subunit

IL27RA
Identifiers
Aliases	IL27RA, CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1, Interleukin 27 receptor, alpha subunit, interleukin 27 receptor subunit alpha
External IDs	OMIM: 605350; MGI: 1355318; HomoloGene: 3562; GeneCards: IL27RA; OMA:IL27RA - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,053,218 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,769,218 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; lymph node; ; blood; ; appendix; ; spleen; ; apex of heart; ; testicle; ; bone marrow cells; ; upper lobe of left lung;
	Top expressed in
	Ileal epithelium; ; lymph node; ; mesenteric lymph nodes; ; blood; ; thymus; ; spleen; ; lactiferous gland; ; choroid plexus of fourth ventricle; ; extraocular muscle; ; subcutaneous adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; interleukin-27 receptor activity; cytokine receptor activity; cytokine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; external side of plasma membrane; receptor complex;
Biological process	negative regulation of type 2 immune response; cell surface receptor signaling pathway; positive regulation of interferon-gamma production; regulation of isotype switching to IgG isotypes; positive regulation of T-helper 1 type immune response; immune response; defense response to Gram-positive bacterium; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; negative regulation of cellular extravasation; negative regulation of T-helper 17 type immune response; negative regulation of T cell extravasation;
	Sources:Amigo / QuickGO
Orthologs
	9466
	50931
	ENSG00000104998; ENSG00000288185
	ENSMUSG00000005465
	Q6UWB1
	O70394
	NM_004843
	NM_016671
	NP_004834
	NP_057880
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.^[5]

^ ^a ^b ^c ENSG00000288185 GRCh38: Ensembl release 89: ENSG00000104998, ENSG00000288185 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005465 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IL27RA interleukin 27 receptor, alpha".

[refGRCh38Ensembl-1] ENSG00000288185 GRCh38: Ensembl release 89: ENSG00000104998, ENSG00000288185 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005465 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IL27RA interleukin 27 receptor, alpha".

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