Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays an important role in the immune response against pathogenes and especially against viruses by mechanisms similar to type I interferons, but targeting primarily cells of epithelial origin and hepatocytes.[5][6]
IL-29 is encoded by the IFNL1 gene located on chromosome 19 in humans.[5][7] It is a pseudogene in mice meaning the IL-29 protein is not produced in them.[5]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000182393 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059128 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Lazear HM, Nice TJ, Diamond MS (July 2015). "Interferon-λ: Immune Functions at Barrier Surfaces and Beyond". Immunity. 43 (1): 15–28. doi:10.1016/j.immuni.2015.07.001. PMC 4527169. PMID 26200010.
- ^ Kelm NE, Zhu Z, Ding VA, Xiao H, Wakefield MR, Bai Q, Fang Y (October 2016). "The role of IL-29 in immunity and cancer". Critical Reviews in Oncology/Hematology. 106: 91–8. doi:10.1016/j.critrevonc.2016.08.002. PMC 7129698. PMID 27637354.
- ^ "Entrez Gene: interleukin 29 (interferon".