Interleukin 4

IL4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL4, Interleukin 4, IL-4
External IDsMGI: 96556; HomoloGene: 491; GeneCards: IL4; OMA:IL4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000589.4

NM_021283

RefSeq (protein)

NP_000580
NP_758858
NP_001341919

NP_067258

Location (UCSC)Chr 5: 132.01 – 132.02 MbChr 11: 53.49 – 53.51 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse
Interleukin 4
analysis of the solution structure of human interleukin 4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques
Identifiers
SymbolIL4
PfamPF00727
Pfam clanCL0053
InterProIPR002354
PROSITEPDOC00655
SCOP22int / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, Th2 cells, eosinophils and basophils.[4] It is closely related and has functions similar to IL-13.

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000869Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Gadani SP, Cronk JC, Norris GT, Kipnis J (November 2012). "IL-4 in the brain: a cytokine to remember". Journal of Immunology. 189 (9): 4213–4219. doi:10.4049/jimmunol.1202246. PMC 3481177. PMID 23087426.