Interleukin 7

IL7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DI2, 3DI3
Identifiers
Aliases	IL7, IL-7, interleukin 7
External IDs	OMIM: 146660; MGI: 96561; HomoloGene: 680; GeneCards: IL7; OMA:IL7 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	78,805,523 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	7,678,820 bp
RNA expression pattern
	Top expressed in
	sperm; ; bronchial epithelial cell; ; testicle; ; Achilles tendon; ; jejunal mucosa; ; lower lobe of lung; ; caput epididymis; ; lymph node; ; right uterine tube; ; rectum;
	Top expressed in
	secondary oocyte; ; lumbar spinal ganglion; ; zygote; ; primary oocyte; ; endothelial cell of lymphatic vessel; ; thymus; ; mesenteric lymph nodes; ; left colon; ; Paneth cell; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; interleukin-7 receptor binding; growth factor activity; cytokine receptor binding; cytokine activity;
Cellular component	extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	negative regulation of catalytic activity; cell-cell signaling; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of organ growth; negative regulation of apoptotic process; bone resorption; humoral immune response; immune response; positive regulation of cell population proliferation; animal organ morphogenesis; regulation of gene expression; homeostasis of number of cells within a tissue; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; T cell lineage commitment; positive regulation of B cell proliferation; positive regulation of T cell differentiation; interleukin-7-mediated signaling pathway; regulation of signaling receptor activity; positive regulation of cytokine-mediated signaling pathway; cytokine-mediated signaling pathway; positive regulation of chemokine production; regulation of peptidyl-tyrosine phosphorylation; positive regulation of gene expression; positive regulation of B cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3574
	16196
	ENSG00000104432
	ENSMUSG00000040329
	P13232
	P10168
	NM_000880; NM_001199886; NM_001199887; NM_001199888
	NM_008371; NM_001313888; NM_001313889; NM_001313890
	NP_000871; NP_001186815; NP_001186816; NP_001186817
	NP_001300817; NP_001300818; NP_001300819; NP_032397
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 7 (IL-7) is a protein^[5] that in humans is encoded by the IL7 gene.^[6]^[7]^[8]

IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes,^[9] dendritic cells,^[10] hepatocytes,^[11] neurons, and epithelial cells,^[12] but is not produced by normal lymphocytes.^[13] A study also demonstrated how the autocrine production of the IL-7 cytokine mediated by T-cell acute lymphoblastic leukemia (T-ALL) can be involved in the oncogenic development of T-ALL and offer novel insights into T-ALL spreading. ^[14]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104432 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040329 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S (June 1988). "Stimulation of B-cell progenitors by cloned murine interleukin-7". Nature. 333 (6173): 571–3. Bibcode:1988Natur.333..571N. doi:10.1038/333571a0. PMID 3259677. S2CID 4315541.
^ Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen AE (January 1989). "Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 302–6. Bibcode:1989PNAS...86..302G. doi:10.1073/pnas.86.1.302. PMC 286452. PMID 2643102.
^ Sutherland GR, Baker E, Fernandez KE, Callen DF, Goodwin RG, Lupton S, Namen AE, Shannon MF, Vadas MA (July 1989). "The gene for human interleukin 7 (IL7) is at 8q12-13". Hum. Genet. 82 (4): 371–2. doi:10.1007/BF00274000. PMID 2786840. S2CID 30870920.
^ Lupton SD, Gimpel S, Jerzy R, et al. (1990). "Characterization of the human and murine IL-7 genes". J. Immunol. 144 (9): 3592–601. doi:10.4049/jimmunol.144.9.3592. PMID 2329282. S2CID 36007598.
^ Heufler C, Topar G, Grasseger A, et al. (September 1993). "Interleukin 7 is produced by murine and human keratinocytes". J. Exp. Med. 178 (3): 1109–14. doi:10.1084/jem.178.3.1109. PMC 2191157. PMID 8350050.
^ Kröncke R, Loppnow H, Flad HD, Gerdes J (October 1996). "Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction". Eur. J. Immunol. 26 (10): 2541–4. doi:10.1002/eji.1830261040. PMID 8898972. S2CID 20992591.
^ Sawa Y, Arima Y, Ogura H, et al. (March 2009). "Hepatic interleukin-7 expression regulates T cell responses". Immunity. 30 (3): 447–57. doi:10.1016/j.immuni.2009.01.007. PMID 19285437.
^ Watanabe M, Ueno Y, Yajima T, et al. (1995). "Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes". J. Clin. Invest. 95 (6): 2945–53. doi:10.1172/JCI118002. PMC 295983. PMID 7769137.
^ Fry TJ, Mackall CL (June 2002). "Interleukin-7: from bench to clinic". Blood. 99 (11): 3892–904. doi:10.1182/blood.V99.11.3892. PMID 12010786.
^ Buffière A, Uzan B, Aucagne R, Hermetet F, Mas M, Nassurdine S, Aznague A, Carmignac V, Tournier B, Bouchot O, Ballerini P, Barata JT, Bastie JN, Delva L, Pflumio F, Quéré R (November 2019). "T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7". Oncogene. 38 (1): 7357–7365. doi:10.1038/s41388-019-0921-4. PMID 31417180. S2CID 199668368.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104432 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040329 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3259677-5] Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S (June 1988). "Stimulation of B-cell progenitors by cloned murine interleukin-7". Nature. 333 (6173): 571–3. Bibcode:1988Natur.333..571N. doi:10.1038/333571a0. PMID 3259677. S2CID 4315541.

[pmid2643102-6] Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen AE (January 1989). "Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 302–6. Bibcode:1989PNAS...86..302G. doi:10.1073/pnas.86.1.302. PMC 286452. PMID 2643102.

[pmid2786840-7] Sutherland GR, Baker E, Fernandez KE, Callen DF, Goodwin RG, Lupton S, Namen AE, Shannon MF, Vadas MA (July 1989). "The gene for human interleukin 7 (IL7) is at 8q12-13". Hum. Genet. 82 (4): 371–2. doi:10.1007/BF00274000. PMID 2786840. S2CID 30870920.

[8] Lupton SD, Gimpel S, Jerzy R, et al. (1990). "Characterization of the human and murine IL-7 genes". J. Immunol. 144 (9): 3592–601. doi:10.4049/jimmunol.144.9.3592. PMID 2329282. S2CID 36007598.

[9] Heufler C, Topar G, Grasseger A, et al. (September 1993). "Interleukin 7 is produced by murine and human keratinocytes". J. Exp. Med. 178 (3): 1109–14. doi:10.1084/jem.178.3.1109. PMC 2191157. PMID 8350050.

[10] Kröncke R, Loppnow H, Flad HD, Gerdes J (October 1996). "Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction". Eur. J. Immunol. 26 (10): 2541–4. doi:10.1002/eji.1830261040. PMID 8898972. S2CID 20992591.

[11] Sawa Y, Arima Y, Ogura H, et al. (March 2009). "Hepatic interleukin-7 expression regulates T cell responses". Immunity. 30 (3): 447–57. doi:10.1016/j.immuni.2009.01.007. PMID 19285437.

[12] Watanabe M, Ueno Y, Yajima T, et al. (1995). "Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes". J. Clin. Invest. 95 (6): 2945–53. doi:10.1172/JCI118002. PMC 295983. PMID 7769137.

[Fry_TJ,_Mackall_CL_2002_3892–904-13] Fry TJ, Mackall CL (June 2002). "Interleukin-7: from bench to clinic". Blood. 99 (11): 3892–904. doi:10.1182/blood.V99.11.3892. PMID 12010786.

[pmid31417180-14] Buffière A, Uzan B, Aucagne R, Hermetet F, Mas M, Nassurdine S, Aznague A, Carmignac V, Tournier B, Bouchot O, Ballerini P, Barata JT, Bastie JN, Delva L, Pflumio F, Quéré R (November 2019). "T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7". Oncogene. 38 (1): 7357–7365. doi:10.1038/s41388-019-0921-4. PMID 31417180. S2CID 199668368.

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