Interleukin 8

CXCL8
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3IL8, 1ICW, 1IKL, 1IKM, 1IL8, 1ILP, 1ILQ, 1QE6, 1ROD, 2IL8, 4XDX
Identifiers
Aliases	CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8, SCYB8
External IDs	OMIM: 146930; HomoloGene: 47937; GeneCards: CXCL8; OMA:CXCL8 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 73,740,519 bp[1] End 73,743,716 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber granulocyte beta cell cartilage tissue olfactory zone of nasal mucosa monocyte mucosa of paranasal sinus bone marrow cells sperm gallbladder n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity protein binding interleukin-8 receptor binding chemokine activity Cellular component extracellular region intracellular anatomical structure extracellular space Biological process G protein-coupled receptor signaling pathway intracellular signal transduction chemokine-mediated signaling pathway cellular response to tumor necrosis factor receptor internalization cellular response to fibroblast growth factor stimulus response to endoplasmic reticulum stress positive regulation of angiogenesis regulation of single stranded viral RNA replication via double stranded DNA intermediate PERK-mediated unfolded protein response induction of positive chemotaxis chemotaxis regulation of cell adhesion immune response cellular response to interleukin-1 angiogenesis positive regulation of neutrophil chemotaxis inflammatory response negative regulation of G protein-coupled receptor signaling pathway response to molecule of bacterial origin cellular response to lipopolysaccharide embryonic digestive tract development signal transduction negative regulation of cell population proliferation calcium-mediated signaling regulation of entry of bacterium into host cell defense response neutrophil chemotaxis neutrophil activation antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity cytokine-mediated signaling pathway leukocyte chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3576 n/a Ensembl ENSG00000169429 n/a UniProt P10145 n/a RefSeq (mRNA) NM_000584 NM_001354840 n/a RefSeq (protein) NP_000575 NP_001341769 n/a Location (UCSC) Chr 4: 73.74 – 73.74 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells^[3] and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel–Palade bodies.^[4][5] In humans, the interleukin-8 protein is encoded by the CXCL8 gene.^[6] IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms.^[7] In culture, a 72 amino acid peptide is the major form secreted by macrophages.^[7]

There are many receptors on the surface membrane capable of binding IL-8; the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). Through a chain of biochemical reactions, IL-8 is secreted and is an important mediator of the immune reaction in the innate immune system response.